| Literature DB >> 3622604 |
J Egido, A Robles, A Ortiz, F Ramirez, E Gonzalez, F Mampaso, M Sanchez Crespo, P Braquet, L Hernando.
Abstract
The effect of steroids, heparin and specific PAF-acether antagonists (BN 52021 and triazolobenzodiazepines) on proteinuria and renal histological changes induced in rats by adriamycin was studied. Adriamycin evoked a marked proteinuria that was unaffected by methylprednisolone and slightly reduced by heparin. In contrast, adriamycin-injected rats treated with PAF-acether antagonists had a low proteinuria, if any, and no ultrastructural glomerular alterations. These data suggest that PAF-acether could play a major role in the occurrence of proteinuria and that PAF-acether antagonists might provide a new therapeutic approach in certain human nephropathies.Entities:
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Year: 1987 PMID： 3622604 DOI： 10.1016/0014-2999(87)90346-3
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432