Automated Scoring of Sleep and Associated Events.

Conventionally, sleep and associated events are scored visually by trained technologists according to the rules summarized in the American Academy of Sleep Medicine Manual. Since its first publication in 2007, the manual was continuously updated; the most recent version as of this writing was published in 2020. Human expert scoring is considered as gold standard, even though there is increasing evidence of limited interrater reliability between human scorers. Significant advances in machine learning have resulted in powerful methods for addressing complex classification problems such as automated scoring of sleep and associated events. Evidence is increasing that these autoscoring systems deliver performance comparable to manual scoring and offer several advantages to visual scoring: (1) avoidance of the rather expensive, time-consuming, and difficult visual scoring task that can be performed only by well-trained and experienced human scorers, (2) attainment of consistent scoring results, and (3) proposition of added value such as scoring in real time, sleep stage probabilities per epoch (hypnodensity), estimates of signal quality and sleep/wake-related features, identifications of periods with clinically relevant ambiguities (confidence trends), configurable sensitivity and rule settings, as well as cardiorespiratory sleep staging for home sleep apnea testing. This chapter describes the development of autoscoring systems since the first attempts in the 1970s up to the most recent solutions based on deep neural network approaches which achieve an accuracy that allows to use the autoscoring results directly for review and interpretation by a physician.