Objective: To evaluate concomitant therapy of oral isotretinoin with multiplex pulsed dye laser and Nd:YAG laser. Methods: A retrospective chart review of patients who received treatment of oral isotretinoin and non-ablative laser therapy to treat acne vulgaris at a single outpatient dermatology clinic site in Ontario, Canada between 2009 and 2017. Results: 187 patients were included, consisting of 45.5 percent males (n=85) and 54.5 percent females (n=102) with a mean age of 21.4 years. 31.6 percent (n=59) of patients reported experiencing side effects from concomitant isotretinoin and NAL therapy, the most common being eczema (n=14), erythema (n=11), significant dry skin/lips/eyes (n=8), flushing (n=6), and bruising (n=6). 99.2 percent of patients achieved clear or almost clear at treatment completion. Of those who expressed satisfaction, 65.2 percent (n=122) reported being satisfied with the treatment and the remaining patients did not report satisfaction nor dissatisfaction. Limitations: Limitations exist mainly due to the absence of standardized lesion counts and a comparator cohort. Thus, it is not possible to comment on whether the combination of isotretinoin and NAL is more efficacious that either treatment alone. Conclusion: Concomitant use of isotretinoin and non-ablative laser therapy is a safe and effective treatment option for acne vulgaris that provides patient satisfaction.
Objective: To evaluate concomitant therapy of oral isotretinoin with multiplex pulsed dye laser and Nd:YAG laser. Methods: A retrospective chart review of patients who received treatment of oral isotretinoin and non-ablative laser therapy to treat acne vulgaris at a single outpatient dermatology clinic site in Ontario, Canada between 2009 and 2017. Results: 187 patients were included, consisting of 45.5 percent males (n=85) and 54.5 percent females (n=102) with a mean age of 21.4 years. 31.6 percent (n=59) of patients reported experiencing side effects from concomitant isotretinoin and NAL therapy, the most common being eczema (n=14), erythema (n=11), significant dry skin/lips/eyes (n=8), flushing (n=6), and bruising (n=6). 99.2 percent of patients achieved clear or almost clear at treatment completion. Of those who expressed satisfaction, 65.2 percent (n=122) reported being satisfied with the treatment and the remaining patients did not report satisfaction nor dissatisfaction. Limitations: Limitations exist mainly due to the absence of standardized lesion counts and a comparator cohort. Thus, it is not possible to comment on whether the combination of isotretinoin and NAL is more efficacious that either treatment alone. Conclusion: Concomitant use of isotretinoin and non-ablative laser therapy is a safe and effective treatment option for acne vulgaris that provides patient satisfaction.
Authors: Yuka Asai; Akerke Baibergenova; Maha Dutil; Shannon Humphrey; Peter Hull; Charles Lynde; Yves Poulin; Neil H Shear; Jerry Tan; John Toole; Catherine Zip Journal: CMAJ Date: 2015-11-16 Impact factor: 8.262
Authors: Seth D Crockett; Carol Q Porter; Christopher F Martin; Robert S Sandler; Michael D Kappelman Journal: Am J Gastroenterol Date: 2010-03-30 Impact factor: 10.864
Authors: Abigail Waldman; Diana Bolotin; Kenneth A Arndt; Jeffrey S Dover; Roy G Geronemus; Anne Chapas; Sanjana Iyengar; Suzanne L Kilmer; Andrew C Krakowski; Naomi Lawrence; Heidi B Prather; Thomas E Rohrer; Bethanee J Schlosser; John Y S Kim; Peter R Shumaker; Leah K Spring; Murad Alam Journal: Dermatol Surg Date: 2017-10 Impact factor: 3.398
Authors: Leah K Spring; Andrew C Krakowski; Murad Alam; Ashish Bhatia; Jeremy Brauer; Joel Cohen; James Q Del Rosso; Lucia Diaz; Jeffrey Dover; Lawrence F Eichenfield; Geoffrey C Gurtner; C William Hanke; Marla N Jahnke; Kristen M Kelly; Shilpi Khetarpal; Megan A Kinney; Moise L Levy; James Leyden; Michael T Longaker; Girish S Munavalli; David M Ozog; Heidi Prather; Peter R Shumaker; Elizabeth Tanzi; Abel Torres; Mara Weinstein Velez; Abigail B Waldman; Albert C Yan; Andrea L Zaenglein Journal: JAMA Dermatol Date: 2017-08-01 Impact factor: 10.282