Literature DB >> 36211133

Dual Use of Artificial Intelligence-powered Drug Discovery.

Fabio Urbina1, Filippa Lentzos2, Cédric Invernizzi3, Sean Ekins1.   

Abstract

An international security conference explored how artificial intelligence (AI) technologies for drug discovery could be misused for de novo design of biochemical weapons. A thought experiment evolved into a computational proof.

Entities:  

Year:  2022        PMID： 36211133      PMCID： PMC9544280          DOI： 10.1038/s42256-022-00465-9

Source DB:  PubMed          Journal:  Nat Mach Intell        ISSN： 2522-5839


  6 in total

1.  The ToxCast program for prioritizing toxicity testing of environmental chemicals.

Authors:  David J Dix; Keith A Houck; Matthew T Martin; Ann M Richard; R Woodrow Setzer; Robert J Kavlock
Journal:  Toxicol Sci       Date:  2006-09-08       Impact factor: 4.849

2.  A robotic platform for flow synthesis of organic compounds informed by AI planning.

Authors:  Connor W Coley; Dale A Thomas; Justin A M Lummiss; Jonathan N Jaworski; Christopher P Breen; Victor Schultz; Travis Hart; Joshua S Fishman; Luke Rogers; Hanyu Gao; Robert W Hicklin; Pieter P Plehiers; Joshua Byington; John S Piotti; William H Green; A John Hart; Timothy F Jamison; Klavs F Jensen
Journal:  Science       Date:  2019-08-09       Impact factor: 47.728

3.  REINVENT 2.0: An AI Tool for De Novo Drug Design.

Authors:  Thomas Blaschke; Josep Arús-Pous; Hongming Chen; Christian Margreitter; Christian Tyrchan; Ola Engkvist; Kostas Papadopoulos; Atanas Patronov
Journal:  J Chem Inf Model       Date:  2020-10-29       Impact factor: 4.956

Review 4.  Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures.

Authors:  Vassiliki Aroniadou-Anderjaska; James P Apland; Taiza H Figueiredo; Marcio De Araujo Furtado; Maria F Braga
Journal:  Neuropharmacology       Date:  2020-09-06       Impact factor: 5.250

5.  Erratum: CATMoS: Collaborative Acute Toxicity Modeling Suite.

Authors:  Kamel Mansouri; Agnes Karmaus; Jeremy Fitzpatrick; Grace Patlewicz; Prachi Pradeep; Domenico Alberga; Nathalie Alepee; Timothy E H Allen; Dave Allen; Vinicius M Alves; Carolina H Andrade; Tyler R Auernhammer; Davide Ballabio; Shannon Bell; Emilio Benfenati; Sudin Bhattacharya; Joyce V Bastos; Stephen Boyd; J B Brown; Stephen J Capuzzi; Yaroslav Chushak; Heather Ciallella; Alex M Clark; Viviana Consonni; Pankaj R Daga; Sean Ekins; Sherif Farag; Maxim Fedorov; Denis Fourches; Domenico Gadaleta; Feng Gao; Jeffery M Gearhart; Garett Goh; Jonathan M Goodman; Francesca Grisoni; Christopher M Grulke; Thomas Hartung; Matthew Hirn; Pavel Karpov; Alexandru Korotcov; Giovanna J Lavado; Michael Lawless; Xinhao Li; Thomas Luechtefeld; Filippo Lunghini; Giuseppe F Mangiatordi; Gilles Marcou; Dan Marsh; Todd Martin; Andrea Mauri; Eugene N Muratov; Glenn J Myatt; Dac-Trung Nguyen; Orazio Nicolotti; Reine Note; Paritosh Pande; Amanda K Parks; Tyler Peryea; Ahsan Polash; Robert Rallo; Alessandra Roncaglioni; Craig Rowlands; Patricia Ruiz; Daniel Russo; Ahmed Sayed; Risa Sayre; Timothy Sheils; Charles Siegel; Arthur C Silva; Anton Simeonov; Sergey Sosnin; Noel Southall; Judy Strickland; Yun Tang; Brian Teppen; Igor V Tetko; Dennis Thomas; Valery Tkachenko; Roberto Todeschini; Cosimo Toma; Ignacio Tripodi; Daniela Trisciuzzi; Alexander Tropsha; Alexandre Varnek; Kristijan Vukovic; Zhongyu Wang; Liguo Wang; Katrina M Waters; Andrew J Wedlake; Sanjeeva J Wijeyesakere; Dan Wilson; Zijun Xiao; Hongbin Yang; Gergely Zahoranszky-Kohalmi; Alexey V Zakharov; Fagen F Zhang; Zhen Zhang; Tongan Zhao; Hao Zhu; Kimberley M Zorn; Warren Casey; Nicole C Kleinstreuer
Journal:  Environ Health Perspect       Date:  2021-07-09       Impact factor: 9.031
  6 in total

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