Literature DB >> 36210424

Changes in the Neuronal Population of the Spinal Cord of Mice with Experimental Autoimmune Encephalomyelitis as a Model of Multiple Sclerosis.

A V Balashov1, V G Pankov2, V P Balashov2, N P Shikhanov3, S V Gushchina2.   

Abstract

We performed a quantitative study of the neuronal population in the spinal cord of mice with acute and chronic model of experimental autoimmune encephalomyelitis. Immunohistological/immunofluorescent analysis with motor neuron marker ChAT revealed a significant decrease in the number of motor neurons in the ventral horns of the lumbar spinal cord in the acute form of autoimmune encephalomyelitis, with the further appearance of large empty (containing no motor neurons) areas in the ventral horns in the chronic form. The development of experimental autoimmune encephalomyelitis is accompanied by degradation and death of neurons, in particular ChAT+ motor neurons.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  experimental autoimmune encephalomyelitis; motoneurons; spinal cord

Mesh：

Year:  2022        PMID： 36210424     DOI： 10.1007/s10517-022-05593-1

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  12 in total

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