Literature DB >> 36210420

Hypoxia Modulates Melanoma Cells Proliferation and Apoptosis via miRNA-210/ISCU/ROS Signaling.

D Suwei1, L Zhen2, L Zhimin2, L Mei3, K Jianping1, P Zhuohui1, X Yanbin4, M Xiang5.   

Abstract

In this study, luciferase reporter assay was used to establish the relationship between miR-210 and ISCU. This research was performed on both cell lines (A2058, G361, and 293T) and tissue samples. We found that miR-210 was upregulated in hypoxia and was elevated in melanoma in comparison with adjacent normal tissues. Expression of ISCU protein was decreased in melanoma tissues, and ISCU gene is a direct target of miR-210. ISCU knockdown with miR-210 enhanced ROS production. The results of our study showed that miR-210/ISCU/ROS axis can serve as a novel therapeutic target in melanoma.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  ISCU; apoptosis; hypoxia; melanoma cell lines; miR-210

Mesh：

Substances：

Year:  2022        PMID： 36210420     DOI： 10.1007/s10517-022-05605-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  10 in total

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