Literature DB >> 36210411

Oligomerization of β-Like DNA Polymerases in the Presence of Fe2+ Ions.

S V Stovbun1, A S Vedenkin2, D V Zlenko1,3, A A Bukhvostov4, D A Kuznetsov1,4.   

Abstract

This work presents data on the relationship between the oligomeric state and catalytic activity of β-like DNA polymerases isolated from three cancer cell lines upon replacement of magnesium ions with iron. It was shown that the suppression of the catalytic activity of β-like DNA polymerases in the presence of divalent iron ions is related to enzyme oligomerization that can be responsible for the suppression of the magnetic isotope effect.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  DNA polymerase; cancer cells; enzyme activity; magnetic isotope effect; oligomers

Mesh：

Substances：

Year:  2022        PMID： 36210411     DOI： 10.1007/s10517-022-05597-x

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.737


  10 in total

Review 1.  Chemistry of enzymatic ATP synthesis: an insight through the isotope window.

Authors:  Anatoly L Buchachenko; Dmitry A Kuznetsov; Natalia N Breslavskaya
Journal:  Chem Rev       Date:  2012-01-25       Impact factor: 60.622

2.  The mitochondria free iron content to limit an isotope effect of (25)Mg (2+) in ATP synthesis: a caution.

Authors:  Andrey A Svistunov; Yuri K Napolov; Alexander A Bukhvostov; Oleg A Shatalov; Renad N Alyautdin; Dmitry A Kuznetsov
Journal:  Cell Biochem Biophys       Date:  2013-06       Impact factor: 2.194

Review 3.  Nuclear spin selectivity in enzymatic catalysis: A caution for applied biophysics.

Authors:  Anatoly Buchachenko; Alexander Bukhvostov; Kirill Ermakov; Dmitry Kuznetsov
Journal:  Arch Biochem Biophys       Date:  2019-04-25       Impact factor: 4.013

4.  The tissue-specific "ferromagnetic attack" on hyperactivation of ATP synthesis by magnesium-25 in mitochondria.

Authors:  Oleg A Shatalov; Andrey A Svistunov; Yuri K Napolov; Alexander A Bukhvostov; Dmitry A Kuznetsov; Renad N Alyautdin
Journal:  Magnes Res       Date:  2012-12       Impact factor: 1.115

5.  Re-characterization of established human retinoblastoma cell lines.

Authors:  Maike Busch; Claudia Philippeit; Andreas Weise; Nicole Dünker
Journal:  Histochem Cell Biol       Date:  2014-10-19       Impact factor: 4.304

6.  Fullerene-based low toxic nanocationite particles (porphyrin adducts of cyclohexyl fullerene-C(60)) to treat hypoxia-induced mitochondrial dysfunction in mammalian heart muscle.

Authors:  Nima Amirshahi; Renad N Alyautdin; Saeed Sarkar; Seyed M Rezayat; Marina A Orlova; Igor V Trushkov; Anatoly L Buchachenko; Dmitry A Kuznetsov
Journal:  Arch Med Res       Date:  2008-08       Impact factor: 2.235

7.  The porphyrin-fullerene nanoparticles to promote the ATP overproduction in myocardium: 25Mg2+-magnetic isotope effect.

Authors:  S M Rezayat; S V S Boushehri; B Salmanian; A H Omidvari; S Tarighat; S Esmaeili; S Sarkar; N Amirshahi; R N Alyautdin; M A Orlova; I V Trushkov; A L Buchachenko; K C Liu; D A Kuznetsov
Journal:  Eur J Med Chem       Date:  2008-07-31       Impact factor: 6.514

8.  A novel electrophoretic technique designed to modify the ratio of magnesium isotopes inside the creatine kinase active sites. A preliminary report.

Authors:  Dmitri A Kouznetsov; Stanislav E Arkhangelsky; Alana G Berdieva; Peter Z Khasigov; Marina A Orlova
Journal:  Isotopes Environ Health Stud       Date:  2004-09       Impact factor: 1.675

Review 9.  DNA polymerase beta (pol β) inhibitors: a comprehensive overview.

Authors:  Khaled H Barakat; Melissa M Gajewski; Jack A Tuszynski
Journal:  Drug Discov Today       Date:  2012-04-25       Impact factor: 7.851

10.  Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Authors:  Glenn S Cowley; Barbara A Weir; Francisca Vazquez; Pablo Tamayo; Justine A Scott; Scott Rusin; Alexandra East-Seletsky; Levi D Ali; William Fj Gerath; Sarah E Pantel; Patrick H Lizotte; Guozhi Jiang; Jessica Hsiao; Aviad Tsherniak; Elizabeth Dwinell; Simon Aoyama; Michael Okamoto; William Harrington; Ellen Gelfand; Thomas M Green; Mark J Tomko; Shuba Gopal; Terence C Wong; Terrence C Wong; Hubo Li; Sara Howell; Nicolas Stransky; Ted Liefeld; Dongkeun Jang; Jonathan Bistline; Barbara Hill Meyers; Scott A Armstrong; Ken C Anderson; Kimberly Stegmaier; Michael Reich; David Pellman; Jesse S Boehm; Jill P Mesirov; Todd R Golub; David E Root; William C Hahn
Journal:  Sci Data       Date:  2014-09-30       Impact factor: 6.444
  10 in total

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