Literature DB >> 3620973

A quantitative study of frontal cortex dendritic microtubules in patients with Alzheimer's disease.

M Paula-Barbosa, M A Tavares, A Cadete-Leite.   

Abstract

The dendritic microtubules (MT) of the frontal cortex layers II and III were studied in 9 patients with Alzheimer's disease (AD) and the results compared with 9 case controls. Dendrites with abnormally oriented MTs and others depleted of these structures were seen. A significant reduction in the number of MTs per unit area was found in AD. It is suggested that microtubular changes in AD can interfere with neuroplasmic transport and thus, be implicated with the dendritic degeneration present in this disease.

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Year:  1987        PMID： 3620973     DOI： 10.1016/0006-8993(87)90188-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Human, but not bovine, oxidized cerebral spinal fluid lipoproteins disrupt neuronal microtubules.

Authors:  M D Neely; L L Swift; T J Montine
Journal:  Lipids       Date:  2000-11       Impact factor: 1.880

2.  Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.

Authors:  Adam D Cash; Gjumrakch Aliev; Sandra L Siedlak; Akihiko Nunomura; Hisashi Fujioka; Xiongwei Zhu; Arun K Raina; Harry V Vinters; Massimo Tabaton; Anne B Johnson; Manuel Paula-Barbosa; Jesus Avíla; Paul K Jones; Rudy J Castellani; Mark A Smith; George Perry
Journal:  Am J Pathol       Date:  2003-05       Impact factor: 4.307

3.  Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases.

Authors:  Haruka Sudo; Peter W Baas
Journal:  Hum Mol Genet       Date:  2010-11-30       Impact factor: 6.150

4.  Hypothesis: microtubules, a key to Alzheimer disease.

Authors:  S S Matsuyama; L F Jarvik
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

5.  Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles.

Authors:  Jing L Guo; Virginia M-Y Lee
Journal:  J Biol Chem       Date:  2011-03-03       Impact factor: 5.157

6.  Inhibition of tubulin polymerization by hypochlorous acid and chloramines.

Authors:  Lisa M Landino; Tara D Hagedorn; Shannon B Kim; Katherine M Hogan
Journal:  Free Radic Biol Med       Date:  2011-01-21       Impact factor: 7.376

7.  The zinc dyshomeostasis hypothesis of Alzheimer's disease.

Authors:  Travis J A Craddock; Jack A Tuszynski; Deepak Chopra; Noel Casey; Lee E Goldstein; Stuart R Hameroff; Rudolph E Tanzi
Journal:  PLoS One       Date:  2012-03-23       Impact factor: 3.240

Review 8.  The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton.

Authors:  Sara H Mokhtar; Maha M Bakhuraysah; David S Cram; Steven Petratos
Journal:  Int J Alzheimers Dis       Date:  2013-12-12

9.  The role of tau in neurodegeneration.

Authors:  Tania F Gendron; Leonard Petrucelli
Journal:  Mol Neurodegener       Date:  2009-03-11       Impact factor: 14.195

10.  PET Imaging of [11C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains.

Authors:  Naresh Damuka; Paul W Czoty; Ashley T Davis; Michael A Nader; Susan H Nader; Suzanne Craft; Shannon L Macauley; Lindsey K Galbo; Phillip M Epperly; Christopher T Whitlow; April T Davenport; Thomas J Martin; James B Daunais; Akiva Mintz; Kiran Kumar Solingapuram Sai
Journal:  Molecules       Date:  2020-05-13       Impact factor: 4.411
  10 in total

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