Giorgio Bianchi1,2, Nicola de'Angelis1,3, Paschalis Gavriilidis4, Iradj Sobhani5,6, Gian Luigi de'Angelis7, Maria Clotilde Carra8. 1. Service of General Surgery, Henri Mondor University Hospital, Creteil, France. 2. Department of Medicine and Surgery, University of Parma, Parma, Italy. 3. Faculté de Santé, Université Paris Est, UPEC, Creteil, France. 4. Department of HBP Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry, CV2 2DX, UK. 5. Department of Gastroenterology, APHP-Henri Mondor University Hospital, Creteil, France. 6. EC2M-EA7375 Research Team, Henri Mondor Campus, Paris East University, Creteil, France. 7. Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University Hospital of Parma, Parma, Italy. 8. Service of Odontology, Unit of Oral and Periodontal Surgery, Rothschild University Hospital and University Paris Cité, 5, rue Santerre, Paris, France. mclotildecarra@gmail.com.
Abstract
PURPOSE: Evidence suggests that patients with obstructive sleep apnea (OSA) are at increased risk of suffering from periodontitis, a chronic inflammatory disease of the tooth-supporting tissues associated with a dysbiotic oral microbiota. This systematic review aims to explore the current literature about the composition of the oral microbiota in patients with OSA compared to those without OSA. METHODS: Medline, Embase, and Cochrane Library were searched in May 2022 to identify original articles investigating the oral microbiota composition and/or oral microbiome (any microbiological technique) of patients with OSA (adults or children) vs. controls. Case report, reviews, and animal studies were excluded. RESULTS: Of over 279 articles initially identified, 8 were selected, of which 3 dealt with pediatric patients. Overall, 344 patients with OSA and 131 controls were included. Five studies used salivary samples, 2 oral mucosal swabs, and 1 subgingival plaque sample. With different methods to characterize oral microbiota, 6/8 studies observed significant differences between patients with OSA patients and controls in the composition and relative abundance of several bacteria species/genera linked to periodontitis. CONCLUSION: Within the limitations of the available literature, the present systematic review indicates that OSA and related conditions (e.g., mouth breathing) are associated with different oral microbiota compositions, which may underlie the association between OSA and periodontitis.
PURPOSE: Evidence suggests that patients with obstructive sleep apnea (OSA) are at increased risk of suffering from periodontitis, a chronic inflammatory disease of the tooth-supporting tissues associated with a dysbiotic oral microbiota. This systematic review aims to explore the current literature about the composition of the oral microbiota in patients with OSA compared to those without OSA. METHODS: Medline, Embase, and Cochrane Library were searched in May 2022 to identify original articles investigating the oral microbiota composition and/or oral microbiome (any microbiological technique) of patients with OSA (adults or children) vs. controls. Case report, reviews, and animal studies were excluded. RESULTS: Of over 279 articles initially identified, 8 were selected, of which 3 dealt with pediatric patients. Overall, 344 patients with OSA and 131 controls were included. Five studies used salivary samples, 2 oral mucosal swabs, and 1 subgingival plaque sample. With different methods to characterize oral microbiota, 6/8 studies observed significant differences between patients with OSA patients and controls in the composition and relative abundance of several bacteria species/genera linked to periodontitis. CONCLUSION: Within the limitations of the available literature, the present systematic review indicates that OSA and related conditions (e.g., mouth breathing) are associated with different oral microbiota compositions, which may underlie the association between OSA and periodontitis.
Authors: Anne E Sanders; Greg K Essick; James D Beck; Jianwen Cai; Shirley Beaver; Tracy L Finlayson; Phyllis C Zee; Jose S Loredo; Alberto R Ramos; Richard H Singer; Monik C Jimenez; Janice M Barnhart; Susan Redline Journal: Sleep Date: 2015-08-01 Impact factor: 5.849
Authors: Adam V Benjafield; Najib T Ayas; Peter R Eastwood; Raphael Heinzer; Mary S M Ip; Mary J Morrell; Carlos M Nunez; Sanjay R Patel; Thomas Penzel; Jean-Louis Pépin; Paul E Peppard; Sanjeev Sinha; Sergio Tufik; Kate Valentine; Atul Malhotra Journal: Lancet Respir Med Date: 2019-07-09 Impact factor: 30.700
Authors: G J Lavigne; A Herrero Babiloni; G Beetz; C Dal Fabbro; K Sutherland; N Huynh; P A Cistulli Journal: J Dent Res Date: 2019-11-08 Impact factor: 6.116
Authors: Chamara V Senaratna; Jennifer L Perret; Caroline J Lodge; Adrian J Lowe; Brittany E Campbell; Melanie C Matheson; Garun S Hamilton; Shyamali C Dharmage Journal: Sleep Med Rev Date: 2016-07-18 Impact factor: 11.609