| Literature DB >> 36204190 |
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Abstract
[This corrects the article DOI: 10.1097/TXD.0000000000001265.].Entities:
Year: 2022 PMID: 36204190 PMCID: PMC9529048 DOI: 10.1097/TXD.0000000000001386
Source DB: PubMed Journal: Transplant Direct ISSN: 2373-8731
Circulating levels of mtDAMPs in patients with AMI or cardiac arrest.
| Patients with cardiac ischemia | Control patients | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| mtDAMP | mtDAMP sampling | Patient population | Sample size | Central tendency | Variability | Patient population | Sample size | Central tendency | Variability | Units | p-value |
| ATP21 | Within 15 minafter ROSC | OHCA | 15 | 221.2(mean) | 26.2(SEM) | Healthy | 8 | 38.7(mean) | 1.2 (SEM) | nmol/L | p<0.001 |
| Cyt c22 | On admission(before PCI) | AMI | 28 | 1.0(mean) | 0.4 (SD) | Healthy | 30 | 1.2(mean) | 0.2(SD) | ng/mL | p=not significant |
| Cyt c23 | 6 hours after standard therapy | AMI | 20 | 0.9(NR) | 0.1(NR) | Healthy | 12 | 0.6(NR) | 0.1(NR) | nmol/mL | p<0.01 |
| Cyt c24 | ≤6 hours of sustained ROSC | OHCA | 102 | 2.2(median) | 0.7, 7.7(IQR) | Healthy | 34 | 0.2(median) | 0.0, 0.9 (IQR) | ng/mL | p<0.001 |
| mtDNA24(D-loop) | ≤6 hours of sustained ROSC | OHCA | 101 | 0.7(median) | 0.4, 1.1(IQR) | Healthy | 46 | 1.4(median) | 0.6, 2.4(IQR) | Fold change | p=not significant |
| mtDNA24 (tRNAleu) | ≤6 hours of sustained ROSC | OHCA | 101 | 1.0(median) | 0.7, 1.3(IQR) | Healthy | 46 | 0.8(median) | 0.5, 1.3(IQR) | Fold change | p=not significant |
| mtDNA25(ND1) | ≤8 hours of admission (before PCI) | AMI | 25 | 3.7(mean) | 0.4(SEM) | Healthy | 25 | 0.2(mean) | 0.1 (SEM) | ng/µl | p<0.05 |
| mtDNA26(ND1) | On admission(before PCI) | AMI | 38 | 478.0(mean) | 106.0(SD) | First onset of angina | 33 | 157.0(mean) | 97.0(SD) | copies/µL | p<0.01 |
| mtDNA27(COX3) | On admission(post ROSC) | OHCA | 20 | 1375.0(mean) | 375.0(SD) | Healthy | 5 | 112.5(mean) | 31.2 (SD) | Arbitrary units | p<0.05 |
| mtDNA27(ND1) | On admission(post ROSC) | OHCA | 20 | 1500.0 (mean) | 406.2(SD) | Healthy | 5 | 125(mean) | 62.5 (SD) | Arbitrary units | p<0.05 |
| mtDNA27(ND2) | On admission(post ROSC) | OHCA | 20 | 1687.5 (mean) | 562.5(SD) | Healthy | 5 | 112.5(mean) | 31.2 (SD) | Arbitrary units | p<0.05 |
| Succinate28 | ≤10 minutes of PCI | AMI-STEMI | 115 | 2.7(mean) | 0.1(SEM) | Stableangina | 11 | 1.4(mean) | 0.1(SEM) | μmol/L | p<0.05 |
| Succinate29 | Notspecified | AMI | 3 | 1.0(mean) | 0.2(SEM) | Healthy | 6 | Not detectable | (SEM) | mmol/L | NR |