Plamen Tzvetanov1, Ivan Lisichkov2, Rossen T Rousseff3, Vishwajit Hegde4, Sergey Kostadinov5. 1. Prof. Tzvetanov is with the Department of Clinical Neurophysiology, Broomfield Hospital Mid Essex Hospital Trust in Broomfield, United Kingdom. 2. Dr. Lisichkov is with the Department of Neurology, Multiprofile Hospital for Active Treatment of Russe in Ruse, Bulgaria. 3. Dr. Rousseff is with the Medical University of Pleven, Bulgaria. 4. Dr. Hegde is a Consultant Neurologisy and Neurophysiologist, University Hospitals of Coventry and Warwickshire in Conventry, United Kingdom. 5. Dr. Kostadinov is an Assistant Professor, Department of General Medicine, Forensic Medicine and Deontology, Faculty of Public Health, Medical University in Pleven, Bulgaria.
Abstract
Objective: We sought to assess the influence of Parkinson's disease (PD) on contingent negative variation (CNV). Patients and Methods: This prospective study included 49 patients with PD (69.7±16.5; 35 male) and 35 age- and sex-matched controls. The PD cohort was subdivided, according to the Hoehn-Yahr Scale, Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS Part III, into 30 cases of uncomplicated PD and 19 cases of advanced PD. CNV was recorded over the frontal and central vertex with a linked bimastoid reference using a dual-stimulus paradigm with interstimulus intervals (ISIs) of 1.7 and 2.0 seconds. Results: In advanced PD, the amplitude of the late CNV over the central vertex was markedly reduced (p<0.005) at ISI of 1.7 seconds and correlated negatively with UPDRS (r=-0.32; p<0.003) and motor score (UPDRS Part III) (r=-0.45; p<0.002). Conclusion: Late CNV amplitude was significantly abnormal in PD and correlated with the severity of the motor manifestations.
Objective: We sought to assess the influence of Parkinson's disease (PD) on contingent negative variation (CNV). Patients and Methods: This prospective study included 49 patients with PD (69.7±16.5; 35 male) and 35 age- and sex-matched controls. The PD cohort was subdivided, according to the Hoehn-Yahr Scale, Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS Part III, into 30 cases of uncomplicated PD and 19 cases of advanced PD. CNV was recorded over the frontal and central vertex with a linked bimastoid reference using a dual-stimulus paradigm with interstimulus intervals (ISIs) of 1.7 and 2.0 seconds. Results: In advanced PD, the amplitude of the late CNV over the central vertex was markedly reduced (p<0.005) at ISI of 1.7 seconds and correlated negatively with UPDRS (r=-0.32; p<0.003) and motor score (UPDRS Part III) (r=-0.45; p<0.002). Conclusion: Late CNV amplitude was significantly abnormal in PD and correlated with the severity of the motor manifestations.
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