Bruno Bergmans1,2, Philip Bourgeois3, Patrick Cras4, Sophie Dethy5, Nina De Klippel6, Gianni Franco7, Gaëtan Garraux8,9, Karine Geens10, Philippe Jacquerye11, Anne Jeanjean12, Frédéric Supiot13, Chris Van der Linden14, Claude Krygier15. 1. Department of Neurology, AZ St-Jan Brugge-Oostende AV, Campus Brugge, Brugge, Belgium. 2. Department of Neurology, Ghent University Hospital, Ghent, Belgium. 3. Department of Neurology, AZ Delta, Roeselare, Belgium. 4. Departement of Neurology, Born Bunge Institute, Faculty of Medicine and Health Sciences, Antwerp University Hospital, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. 5. Department of Neurology, CHU-Tivoli, La Louvière, Belgium. 6. Department of Neurology, Jessa Hospital, Hasselt, Belgium. 7. Department of Neurology, CHU UCL Namur Dinant, Collaborator ULiège, Dinant, Belgium. 8. MoVeRe Group, Cyclotron Research Center, University of Liege, Liège, Belgium. 9. Department of Neurology, University Hospital Center, Liège, Belgium. 10. Department of Neurology, AZ Klina, Brasschaat, Belgium. 11. Department of Neurology, La Louvière, Belgium. 12. Department of Neurology, Saint Luc University Hospital, UCLouvain, Brussels, Belgium. 13. Department of Neurology, Erasme Academic Hospital, Anderlecht, Belgium. 14. Department of Neurology, AZ Sint-Lucas Hospital, Ghent, Belgium. 15. Medical Department, Zambon Belgium, Brussels, Belgium. claude.krygier@zambongroup.com.
Abstract
BACKGROUND: Safinamide is a recent multimodal antiparkinsonian drug that inhibits monoamine oxidase B and modulates the glutamatergic system with positive effects on motor and nonmotor symptoms of Parkinson's disease (PD). This post-hoc analysis of the European SYNAPSES study provides first-time data on the use of safinamide in routine clinical practice in Belgium. OBJECTIVE: To describe the efficacy and safety of safinamide in Belgian PD patients in real-life conditions. METHODS: Post-hoc analysis of the Belgian cohort from the European SYNAPSES trial, which was an observational, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months. Analyses were performed in the overall population and according to different criteria such as the age limit (> 75 years), presence or absence of relevant comorbidities, presence or absence of psychiatric conditions such as depression and anxiety, patients on levodopa monotherapy or levodopa in combination with other treatments, patients on rasagiline before inclusion or not. RESULTS: Of the 172 patients included, 29.2% were > 75 years, 58.9% had relevant comorbidities and 32.7% had psychiatric conditions. Almost all the patients reported motor (98.8%) or non-motor (86.3%) symptoms. During the study, 36.3% of patients reported drug-related reactions. The adverse drug reactions were those already described in the patients' information leaflet. The majority were mild or moderate and completely resolved and no differences were detected between the subgroups of patients. Almost 35% of the patients demonstrated a clinically significant improvement in the UPDRS and 50% of the patients with wearing-off at baseline, did not report wearing-off anymore after one year of treatment. Patients under levodopa monotherapy compared to patients receiving levodopa combined with other antiparkinsonian treatments benefit more from safinamide treatment. Patients switched from rasagiline to safinamide seemed also to benefit more from safinamide treatment. CONCLUSION: The study confirms the excellent safety and efficacy profile of safinamide, particularly in more vulnerable groups of patients such as the elderly and patients with significant comorbidities or psychiatric conditions such as depression or anxiety.
BACKGROUND: Safinamide is a recent multimodal antiparkinsonian drug that inhibits monoamine oxidase B and modulates the glutamatergic system with positive effects on motor and nonmotor symptoms of Parkinson's disease (PD). This post-hoc analysis of the European SYNAPSES study provides first-time data on the use of safinamide in routine clinical practice in Belgium. OBJECTIVE: To describe the efficacy and safety of safinamide in Belgian PD patients in real-life conditions. METHODS: Post-hoc analysis of the Belgian cohort from the European SYNAPSES trial, which was an observational, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months. Analyses were performed in the overall population and according to different criteria such as the age limit (> 75 years), presence or absence of relevant comorbidities, presence or absence of psychiatric conditions such as depression and anxiety, patients on levodopa monotherapy or levodopa in combination with other treatments, patients on rasagiline before inclusion or not. RESULTS: Of the 172 patients included, 29.2% were > 75 years, 58.9% had relevant comorbidities and 32.7% had psychiatric conditions. Almost all the patients reported motor (98.8%) or non-motor (86.3%) symptoms. During the study, 36.3% of patients reported drug-related reactions. The adverse drug reactions were those already described in the patients' information leaflet. The majority were mild or moderate and completely resolved and no differences were detected between the subgroups of patients. Almost 35% of the patients demonstrated a clinically significant improvement in the UPDRS and 50% of the patients with wearing-off at baseline, did not report wearing-off anymore after one year of treatment. Patients under levodopa monotherapy compared to patients receiving levodopa combined with other antiparkinsonian treatments benefit more from safinamide treatment. Patients switched from rasagiline to safinamide seemed also to benefit more from safinamide treatment. CONCLUSION: The study confirms the excellent safety and efficacy profile of safinamide, particularly in more vulnerable groups of patients such as the elderly and patients with significant comorbidities or psychiatric conditions such as depression or anxiety.
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