| Literature DB >> 36199832 |
Lutul D Farrow1, Michael J Scarcella1, Christa L Wentt1, Morgan H Jones1, Kurt P Spindler1, Isaac Briskin1, Brian M Leo1, Brett W McCoy1, Anthony A Miniaci1, Richard D Parker1, James T Rosneck1, Frank M Sabo1, Paul M Saluan1, Alfred Serna1, Kim L Stearns1, Gregory J Strnad1, James S Williams1.
Abstract
Background: It is unknown whether race- or insurance-based disparities in health care exist regarding baseline knee pain, knee function, complete meniscal tear, or articular cartilage damage in patients who undergo anterior cruciate ligament reconstruction (ACLR). Hypothesis: Black patients and patients with Medicaid evaluated for ACLR would have worse baseline knee pain, worse knee function, and greater odds of having a complete meniscal tear. Study Design: Cross-sectional study; Level of evidence, 3.Entities:
Keywords: anterior cruciate ligament reconstruction; insurance status; meniscal tear; patient-reported outcome; racial disparities
Year: 2022 PMID: 36199832 PMCID: PMC9528024 DOI: 10.1177/23259671221117486
Source DB: PubMed Journal: Orthop J Sports Med ISSN: 2325-9671
Figure 1.The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) diagram. ACLR, anterior cruciate ligament reconstruction; APM, arthroscopic partial meniscectomy; PROM, patient-reported outcome measure; T0, time zero (baseline).
Descriptive Statistics by Race
| Race |
| |||||
|---|---|---|---|---|---|---|
| Variable | White, n = 1190 | Black, n = 201 | Other, n = 72 | White vs Black | White vs Other | Black vs Other |
| Age at surgery, y | 22.0 [17.0-36.0] | 21.0 [17.0-31.0] | 24.0 [17.0-32.0] | .313 | .781 | .727 |
| Sex | .390 | .332 | .390 | |||
| Male | 620 (52.1) | 112 (55.7) | 45 (62.5) | |||
| Female | 570 (47.9) | 89 (44.3) | 27 (37.5) | |||
| Insurance type |
|
|
| |||
| Commercial | 1107 (93.0) | 116 (57.7) | 60 (83.3) | |||
| Medicaid | 83 (7.0) | 85 (42.3) | 12 (16.7) | |||
| BMI | 26.9 ± 5.61 | 28.4 ± 7.37 | 26.4 ± 4.86 |
| .763 |
|
| Years of education | 13.0 [11.0-16.0] | 12.0 [11.0-14.0] | 14.0 [11.0-16.0] |
| .167 |
|
| Years of education by group | .198 | .336 | .198 | |||
| ≥12 | 785 (66.0) | 121 (60.2) | 52 (72.2) | |||
| <12 | 405 (34.0) | 80 (39.8) | 20 (27.8) | |||
| Smoking status |
| .755 | .057 | |||
| Never | 955 (80.3) | 141 (70.1) | 57 (79.2) | |||
| Quit | 159 (13.4) | 17 (8.5) | 9 (12.5) | |||
| Current | 76 (6.4) | 43 (21.4) | 6 (8.33) | |||
| Baseline VR-12 MCS | 56.3 [48.1-61.3] | 53.3 [43.1-59.4] | 55.4 [47.3-60.3] |
| .614 | .160 |
| Meniscus root tear | >.999 | >.999 | >.999 | |||
| No | 1151 (96.7) | 195 (97.0) | 70 (97.2) | |||
| Yes | 39 (3.3) | 6 (3.0) | 2 (2.8) | |||
| Tear location |
| .866 | .405 | |||
| None | 606 (50.9) | 81 (40.3) | 36 (50.0) | |||
| Medial | 205 (17.2) | 32 (15.9) | 14 (19.4) | |||
| Lateral | 252 (21.2) | 49 (24.4) | 13 (18.1) | |||
| Both | 127 (10.7) | 39 (19.4) | 9 (12.5) | |||
| Baseline KOOS | ||||||
| Pain | 72.2 [58.3-83.3] | 72.2 [50.0-83.3] | 72.2 [61.1-86.1] | .412 | .563 | .412 |
| Function | 68.2 [61.4-78.0] | 68.2 [58.0-78.0] | 69.2 [58.0-78.8] | .151 | .647 | .647 |
| Extent of OA | .248 | .575 | .248 | |||
| Normal or G1 | 809 (68.0) | 123 (61.2) | 53 (73.6) | |||
| G2 | 184 (15.5) | 39 (19.4) | 10 (13.9) | |||
| G3, G4, or OCD | 197 (16.6) | 39 (19.4) | 9 (12.5) | |||
Data are reported as median [interquartile range], n (%), or mean ± SD. Boldface P values indicate a statistically significant difference between groups compared (P < .05). BMI, body mass index; G1, G2, G3, G4, grades 1-4; KOOS, Knee injury and Osteoarthritis Outcome Score; OA, osteoarthritis; OCD, osteochondral defect; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
Linear Regression Model Results: KOOS Pain
| Variable | Estimate (95% CI) |
|
|---|---|---|
| Age | –0.41 (–0.5 to –0.32) |
|
| Sex, female (vs male) | –2.56 (–4.27 to –0.84) |
|
| Race | ||
| Black (vs White) | 0.7 (–2.47 to 3.86) | .666 |
| Other (vs White) | 0.48 (–3.77 to 4.74) | .823 |
| BMI | –0.54 (–0.69 to –0.39) |
|
| Years of education | 0.56 (0.27 to 0.84) |
|
| Smoking status | ||
| Quit (vs never) | –0.69 (–3.35 to 1.97) | .611 |
| Current (vs never) | –7.92 (–11.15 to –4.7) |
|
| Baseline VR-12 MCS | 0.37 (0.29 to 0.46) |
|
| Insurance, Medicaid (vs commercial) | –6.13 (–9.87 to –2.38) |
|
| Tear location | ||
| Medial (vs no tear) | –0.19 (–2.55 to 2.17) | .873 |
| Lateral (vs no tear) | 1.48 (–0.7 to 3.67) | .183 |
| Both (vs no tear) | –0.47 (–3.19 to 2.25) | .733 |
| Race × insurance | ||
| Black × Medicaid | 2.17 (–3.69 to 8.03) | .468 |
| Other × Medicaid | 1.1 (–9.72 to 11.91) | .843 |
Boldface P values indicate a statistically significant difference between groups compared (P < .05). BMI, body mass index; KOOS, Knee injury and Osteoarthritis Outcome Score; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
This value represents the estimated change in KOOS Pain. As an example, the estimated change in KOOS Pain per 1-year increase in patient age was –0.41 points. The estimated difference in KOOS Pain among female versus male patients was –2.56 points.
Figure 2.Variable importance plot for KOOS Pain. The relative importance of each variable in explaining KOOS Pain was ranked according to the increase in AIC upon removal from the full model. When race or insurance was removed, the race × insurance interaction was removed as well. ACLR, anterior cruciate ligament reconstruction; AIC, Akaike information criterion; BMI, body mass index; KOOS, Knee injury and Osteoarthritis Outcome Score; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
Linear Regression Model Results: KOOS Function
| Variable | Estimate (95% CI) |
|
|---|---|---|
| Age | –0.29 (–0.36 to –0.22) |
|
| Sex, female (vs male) | –2.19 (–3.58 to –0.81) |
|
| Race | ||
| Black (vs White) | 0.29 (–2.28 to 2.85) | .826 |
| Other (vs White) | –1.69 (–5.13 to 1.76) | .337 |
| BMI | –0.4 (–0.52 to –0.28) |
|
| Years of education | 0.4 (0.18 to 0.63) |
|
| Smoking status | ||
| Quit (vs never) | 0.29 (–1.87 to 2.45) | .792 |
| Current (vs never) | –7.11 (–9.72 to –4.5) |
|
| Baseline VR-12 MCS | 0.28 (0.22 to 0.35) |
|
| Insurance, Medicaid (vs commercial) | –2.86 (–5.89 to 0.18) | .065 |
| Tear location | ||
| Medial (vs no tear) | 0.44 (–1.47 to 2.35) | .652 |
| Lateral (vs no tear) | 1.01 (–0.75 to 2.78) | .262 |
| Both (vs no tear) | 1.28 (–0.92 to 3.48) | .255 |
| Race × insurance | ||
| Black × Medicaid | –0.48 (–5.22 to 4.27) | .844 |
| Other × Medicaid | 0.3 (–8.46 to 9.06) | .946 |
Boldface P values indicate statistical significance (P < .05). BMI, body mass index; KOOS, Knee injury and Osteoarthritis Outcome Score; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
This value represents the estimated change in KOOS Function. As an example, the estimated change in KOOS Function per 1-year increase in patient age is –0.29 points. The estimated difference in KOOS Function among female versus male patients is –2.19 points.
Figure 3.Variable importance plot for KOOS Function. The relative importance of each variable in explaining KOOS Function was ranked according to the increase in AIC upon removal from the full model. When race or insurance was removed, the race × insurance interaction was removed as well. ACLR, anterior cruciate ligament reconstruction; AIC, Akaike information criterion; BMI, body mass index; KOOS, Knee injury and Osteoarthritis Outcome Score; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
Figure 4.Variable importance plot for complete meniscal tear. The relative importance of each variable in explaining complete meniscal tear was ranked according to the increase in AIC upon removal from the full model. When race or insurance was removed, the race × insurance interaction was removed as well. ACLR, anterior cruciate ligament reconstruction; AIC, Akaike information criterion; BMI, body mass index; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
Summary of Significant Variables in Multivariate Analysis
| Variable | KOOS Pain | KOOS Function | Complete Meniscal Tear |
|---|---|---|---|
| Age | X | X | — |
| Sex, female (vs male) | X | X | X |
| Race | — | — | — |
| Black (vs White) | — | — | — |
| Other (vs White) | — | — | — |
| BMI | X | X | — |
| Years of education | X | X | X |
| Smoking status | — | — | — |
| Quit (vs never) | — | — | — |
| Current (vs never) | X | X | — |
| Baseline VR-12 MCS | X | X | — |
| Insurance | — | — | — |
| Medicare (vs commercial) | X | — | — |
| Medicaid (vs commercial) | — | — | — |
| Meniscal tear, yes (vs no) | — | — | — |
| Tear location | — | — | — |
| Medial (vs no tear) | — | — | — |
| Lateral (vs no tear) | — | — | — |
| Both (vs no tear) | — | — | — |
| Race × insurance | — | — | — |
| Black × Medicare | — | — | — |
| Other × Medicare | — | — | — |
| Black × Medicaid | — | — | — |
| Other × Medicaid | — | — | — |
| Patient age × years of education | — | — | — |
X indicates significant; — indicates not significant. BMI, body mass index; KOOS, Knee injury and Osteoarthritis Outcome Score; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
Proportional Odds Regression Model Results: Complete Meniscal Tear
| Variable | Odds Ratio (95% CI) |
|
|---|---|---|
| Age | 1.01 (1-1.02) | .143 |
| Sex, female (vs male) | 0.67 (0.55-0.83) |
|
| Race | ||
| Black (vs White) | 1.22 (0.83-1.81) | .313 |
| Other (vs White) | 1.15 (0.68-1.94) | .607 |
| BMI | 1.01 (0.99-1.03) | .262 |
| Years of education | 0.95 (0.92-0.99) |
|
| Smoking status | ||
| Quit (vs never) | 0.93 (0.67-1.29) | .669 |
| Current (vs never) | 1 (0.67-1.5) | .982 |
| Baseline VR-12 MCS | 1 (0.99-1.01) | .660 |
| Insurance, Medicaid (vs commercial) | 0.94 (0.59-1.5) | .797 |
| Race × insurance | ||
| Black × Medicaid | 1.49 (0.71-3.12) | .291 |
| Other × Medicaid | 0.59 (0.15-2.25) | .436 |
Boldface P values indicate statistical significance (P < .05). BMI, body mass index; VR-12 MCS, Veterans RAND 12-Item Health Survey Mental Component Score.
This value represents the increased odds of a complete meniscal tear. As an example, the odds of a complete meniscal tear increases 1.01-fold per 1-year increase in patient age.