Literature DB >> 36199532

Subpopulation cooperation renders drug resistance of hepatobiliary tumor organoids.

Kuo Qi1, Rong Liu2.   

Abstract

Hepatobiliary tumors are of high grade of heterogeneity, which is recognized as a key contributor to drug resistance and poor disease prognosis. However, the intrinsic mechanism between heterogeneity and drug response in hepatobiliary tumor is still largely unknown. Using tumor organoid models, Wang and her colleagues have found that cooperation among distinct subpopulations might be a key mechanism for drug resistance in hepatobiliary tumor. © Chinese Journal of Cancer Research. All rights reserved.

Entities:  

Keywords:  Hepatobiliary tumors; drug resistance; organoid

Year:  2022        PMID： 36199532      PMCID： PMC9468021          DOI： 10.21147/j.issn.1000-9604.2022.04.10

Source DB:  PubMed          Journal:  Chin J Cancer Res        ISSN： 1000-9604            Impact factor:   4.026


  5 in total

Review 1.  EMT, CSCs, and drug resistance: the mechanistic link and clinical implications.

Authors:  Tsukasa Shibue; Robert A Weinberg
Journal:  Nat Rev Clin Oncol       Date:  2017-04-11       Impact factor: 66.675

Review 2.  Intra-tumor heterogeneity from a cancer stem cell perspective.

Authors:  Pramudita R Prasetyanti; Jan Paul Medema
Journal:  Mol Cancer       Date:  2017-02-16       Impact factor: 27.401

3.  NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44.

Authors:  Shigemi Koyama; Hiroyuki Tsuchiya; Masataka Amisaki; Hiromi Sakaguchi; Soichiro Honjo; Yoshiyuki Fujiwara; Goshi Shiota
Journal:  Int J Mol Sci       Date:  2020-03-11       Impact factor: 5.923

4.  Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

Authors:  Georgios Vlachogiannis; Somaieh Hedayat; Alexandra Vatsiou; Yann Jamin; Javier Fernández-Mateos; Khurum Khan; Andrea Lampis; Katherine Eason; Ian Huntingford; Rosemary Burke; Mihaela Rata; Dow-Mu Koh; Nina Tunariu; David Collins; Sanna Hulkki-Wilson; Chanthirika Ragulan; Inmaculada Spiteri; Sing Yu Moorcraft; Ian Chau; Sheela Rao; David Watkins; Nicos Fotiadis; Maria Bali; Mahnaz Darvish-Damavandi; Hazel Lote; Zakaria Eltahir; Elizabeth C Smyth; Ruwaida Begum; Paul A Clarke; Jens C Hahne; Mitchell Dowsett; Johann de Bono; Paul Workman; Anguraj Sadanandam; Matteo Fassan; Owen J Sansom; Suzanne Eccles; Naureen Starling; Chiara Braconi; Andrea Sottoriva; Simon P Robinson; David Cunningham; Nicola Valeri
Journal:  Science       Date:  2018-02-23       Impact factor: 47.728

5.  Single-Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids.

Authors:  Yan Zhao; Zhi-Xuan Li; Yan-Jing Zhu; Jing Fu; Xiao-Fang Zhao; Ya-Ni Zhang; Shan Wang; Jian-Min Wu; Kai-Ting Wang; Rui Wu; Cheng-Jun Sui; Si-Yun Shen; Xuan Wu; Hong-Yang Wang; Dong Gao; Lei Chen
Journal:  Adv Sci (Weinh)       Date:  2021-03-23       Impact factor: 16.806
  5 in total

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