Literature DB >> 3619914

Rapid oxidative stress induced by N-nitrosamines.

M Ahotupa, V Bussacchini-Griot, J C Béréziat, A M Camus, H Bartsch.   

Abstract

We have investigated the generation of prooxidant state shortly after administration of N-nitrosamines (NA) to rats. N-Nitrosodimethylamine (NDMA) was found to increase ethane exhalation (EE) rapidly in a dose-related manner. EE remained elevated for several days after single doses of NDMA. Similarly, lipid peroxidation (LP) in the liver (measured by four methods) increased rapidly showing a peak 20 min after NDMA dose. The increase of LP was preceded by a decrease in retinol concentration in the liver. N-Nitrosodiethanolamine, too, increased EE and LP in the liver, whereas N-nitrosomethylbenzylamine had no effect. Thus, hepatocarcinogenic NA induced LP in their target tissue, and the LP enhancing effects of NA were not related to their acute toxic effects.

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Year:  1987        PMID： 3619914     DOI： 10.1016/0006-291x(87)90753-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

Review 1.  Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview.

Authors:  Jorge Pereira; Priscilla Porto-Figueira; Carina Cavaco; Khushman Taunk; Srikanth Rapole; Rahul Dhakne; Hampapathalu Nagarajaram; José S Câmara
Journal:  Metabolites       Date:  2015-01-09

2.  Potential role of oxidative stress-induced apoptosis in mediating chromosomal rearrangements in nasopharyngeal carcinoma.

Authors:  Sang-Nee Tan; Sai-Peng Sim; Alan S B Khoo
Journal:  Cell Biosci       Date:  2016-05-25       Impact factor: 7.133

3.  Comparisons of Curative Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaf Extract and Cu-Chlorophyllin on Sodium Nitrate-Induced Oxidative Stress in Rats.

Authors:  Suparmi Suparmi; Minidian Fasitasari; Martanto Martosupono; Jubhar Christian Mangimbulude
Journal:  J Toxicol       Date:  2016-12-08

4.  Cigarette- and snus-modified association between unprotected exposure to noise from hunting rifle caliber weapons and high frequency hearing loss. A cross-sectional study among swedish hunters.

Authors:  Louise Honeth; Peter Ström; Alexander Ploner; Dan Bagger-Sjöbäck; Ulf Rosenhall; Olof Nyrén
Journal:  Noise Health       Date:  2016 Nov-Dec       Impact factor: 0.867

5.  Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis.

Authors:  Sang-Nee Tan; Sai-Peng Sim; Alan S B Khoo
Journal:  BMC Mol Biol       Date:  2018-12-04       Impact factor: 2.946

Review 6.  Assessment, origin, and implementation of breath volatile cancer markers.

Authors:  Hossam Haick; Yoav Y Broza; Pawel Mochalski; Vera Ruzsanyi; Anton Amann
Journal:  Chem Soc Rev       Date:  2013-12-04       Impact factor: 54.564
  6 in total

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