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Literature DB >> 36196300

Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations.

Arthur H Totten¹, Gulbu Uzel², Pavel P Khil^1,2, Jung-Ho Youn¹, Jennifer Treat², Craig D Soutar¹, Steven M Holland², John P Dekker^1,2, Christa S Zerbe².

Abstract

Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options. Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.

Entities: Chemical

Keywords: Mycoplasma orale; PI3KR1; immunodeficiency; phosphoinositide-3-kinase regulatory subunit 1

Year: 2022 PMID： 36196300 PMCID： PMC9522676 DOI： 10.1093/ofid/ofac472

Source DB: PubMed Journal: Open Forum Infect Dis ISSN： 2328-8957 Impact factor: 4.423

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