| Literature DB >> 36192702 |
Nathalie Zappella1, Chadi Dirani2, Brice Lortat Jacob2, Sébastien Tanaka2,3, Elie Kantor2, Adnan El Kalai2, Yassine Rkik2, Aurélie Gouel Cheron2,4,5,6, Alexy Tran Dinh2,4, Philippe Montravers2,4,7.
Abstract
BACKGROUND: During the COVID-19 first wave in France, the capacity of intensive care unit (ICU) beds almost doubled, mainly because of the opening of temporary ICUs with staff and equipment from anaesthesia.Entities:
Keywords: ARDS; COVID-19; Intensive care; Sanitary crisis; Temporary ICU
Mesh:
Year: 2022 PMID: 36192702 PMCID: PMC9527134 DOI: 10.1186/s12871-022-01845-9
Source DB: PubMed Journal: BMC Anesthesiol ISSN: 1471-2253 Impact factor: 2.376
Fig. 1Criteria of admission to the temporary ICU
Fig. 2Flowchart of the study
Description of the cohort and comparison between patients initially managed in the classical ICU and patients initially managed in the temporary ICU
| All patients | Classical ICU | Temporary ICU | |||
|---|---|---|---|---|---|
| Epidemiological data | |||||
| Age, years, median [IQR] | 56 [48-63.5] | 53 [47.5-62.8] | 57 [50-65] | 0.58 | |
| Male sex, n (%) | 41 (69.5) | 17 (77.3) | 11 (64.9) | 0.48 | |
| Time between the first symptoms to hospital admission, days, median [IQR] | 7 [4-10] | 6 [3-9] | 7 [5-10] | 0.09 | |
| Time between the hospital and ICU admission, days, median [IQR] | 1 [0-2] | 0 [0-1] | 1 [0-2] | 0.15 | |
| Comorbidities | |||||
| Body Mass Index (kg/m2), median [IQR] | 27.8 [ 24.6-31 ] | 26 [24.4-29.6] | 28.9 [24.9-31.1] | 0.35 | |
| Hypertension, n (%) | 30 (50.8) | 12 (54.6) | 18 (48.7) | 0.34 | |
| Diabetes, n (%) | 19 (32.2) | 11 (50) | 8 (21.6) | 0.07 | |
| Chronic renal insufficiency, n (%) | 4 (6.8) | 2 (9.1) | 2 (5.4) | 0.16 | |
| Immunosuppression, n (%) | 6 (10.2) | 3 (13.6) | 3 (8.1) | 0.64 | |
| Active smoking, n (%) | 6 (10.2) | 2 (9.1) | 4 (10.8) | 0.71 | |
| Severity on admission | |||||
| SOFA score, median [IQR] | 5 [4-7] | 4.5 [3-6.8] | 5 [4-7] | 0.40 | |
| SAPS II score, median [IQR] | 41 [30-53.5] | 46.5 [26-54] | 40 [31-53] | 0.84 | |
| Computed tomographic data | |||||
| Chest CT-scan, n (%) | 42 (71.1) | 15 (68.2) | 27 (73) | 0.77 | |
| Chest CT-scan degree of lung involvement | Minimal < 25% | 5 (11.9) | 2 (13.3) | 3 (11.1) | 1 |
| Mild 25-50% | 23 (54.8) | 7 (46.7) | 16 (59.3) | ||
| Moderate or severe > 50% | 14 (33.3) | 6 (40) | 8 (29.6) | ||
| Time between Chest CT-scan and ICU admission, days, median [IQR] | -0.6 [-2;0] | 0 [-2;0] | -1 [-2;0] | 0.40 | |
| Ventilator features on admission | |||||
| Invasive mechanical ventilation, n (%) | 53 (90) | 17 (77.3) | 36 (97.3) | 0.02 | |
| PEEP, cmH2O, median [IQR] | 10 [10-11] | 10 [10-11] | 10 [10-10.8] | 0.81 | |
| FiO2, %, median [IQR] | 100 [70-100] | 100 [60-100] | 100 [70-100] | 0.61 | |
| PaO2/FiO2, median [IQR] | 130 [79.3-191.5] | 160 [89-205] | 122 [78.5-169] | 0.42 | |
| Use of adjunct measures and outcome | |||||
| Continuous neuromuscular blockers, n (%) | 48 (81.4) | 15 (68.2) | 33 (89.2) | 0.08 | |
| Prone positioning, n (%) | 41 (69.5) | 13 (59.1) | 28 (75.7) | 0.24 | |
| ECMO, n (%) | 11 (18.6) | 6 (27.3) | 5 (13.5) | 0.30 | |
| Vasopressive therapy, n (%) | 39 (66.1) | 12 (54.5) | 27 (73) | < 0.01 | |
| Renal replacement therapy for AKI, n (%) | 11 (18.6) | 4 (18.2) | 7 (18.9) | 1 | |
| Tracheotomy, n (%) | 14 (23.7) | 4 (18.2) | 10 (27) | 0.54 | |
| Interregional transfer | 12 (20.3) | 2 (9.1) | 10 (27) | 0.06 | |
| Ventilator-associated pneumonia, n (%) | 30 (50.8) | 8 (47) | 22 (61.1) | 0.11 | |
| Early ventilator-associated pneumonia, n (%) | 4 (6.8) | 1 (5.9) | 3 (8.3) | 1 | |
| Time between invasive ventilation and ventilator-associated pneumonia, days, median [IQR] | 7 [5-10] | 8 [5-10] | 7 [5-11.5] | 0.38 | |
| Duration of invasive ventilation, days | All patients, median [IQR] | 14 [7.5–17.5] | 9 [3.3-19.8] | 16 [8-25] | 0.07 |
| Survivors, median [IQR] | 16 [5.3-27.3] | 11[0-20] | 20 [8-29] | 0.10 | |
| ICU length of stay, days | All patients, median [IQR] | 15 [8-28] | 8.5 [3.8-19.8] | 17 [9-28] | 0.05 |
| Survivors, median [IQR] | 19.5 [8.5-32] | 12 [2-26] | 26 [11-34] | 0.11 | |
| ICU mortality rate, n (%) | 21 (35.6) | 9 (40.9) | 12 (32.4) | 0.58 | |
| Day-90 mortality rate, n (%) | 21 (35.6) | 9 (40.9) | 12 (32.4) | 0.58 | |
Fig. 3Distribution of admissions over time
Comparison between survivors and patients who died in the ICU
| Survivors | Deceased in the ICU | |||
|---|---|---|---|---|
| Epidemiological data | ||||
| Age, years, median [IQR] | 54.5 [46.3-60.5] | 59 [51-68] | 0.11 | |
| Male sex, n (%) | 27 (71) | 14 (66.7) | 0.77 | |
| Body Mass Index (kg/m2), median [IQR] | 26.4 [23.4-29.4] | 30.2 [26.4-35.4] | 0.04 | |
| Severity on admission | ||||
| SOFA score, median [IQR] | 4.5 [3-6] | 5 [4-7] | 0.11 | |
| SAPS II score, median [IQR] | 35 [25.5-42] | 51 [45-60] | < 0.01 | |
| Tomodensitometric data | ||||
| Chest CT-scan, n (%) | 34 (89.5) | 8 (38.1) | < 0.01 | |
| Chest CT degree of involvement | Minimal < 25% | 4 (11.8) | 1 (12.5) | 0.55 |
| Mild 25-50% | 20 (58.8) | 3 (37.5) | ||
| Moderate or severe > 50% | 10 (29.4) | 4 (50) | ||
| Ventilator features on admission | ||||
| Invasive mechanical ventilation, n (%) | 32 (84) | 21 (100) | 0.08 | |
| PEEP, cmH2O, median [IQR] | 10 [10-10] | 10 [10-12] | 0.10 | |
| FiO2, %, median [IQR] | 100 [62.5-100] | 100 [72.5-100] | 0.50 | |
| PaO2/FiO2, median [IQR] | 151.5 [108.8-230.2] | 89.5 [66-146.5] | < 0.01 | |
| PaCO2, mmHg, median [IQR] | 41 [38.5-42.3] | 40 [35.3-43.8] | 0.36 | |
| Drug therapies | ||||
| Antibiotic therapy, n (%) | 37 (97.4) | 20 (95.2) | 1 | |
| Before ICU admission, n (%) | 17 (44.7) | 10 (47.6) | 1 | |
| During ICU stay, n (%) | 37 (97.4) | 19 (90.5) | 0.29 | |
| Antiviral therapy, n (%) | 10 (26.3) | 5 (23.8) | 1 | |
| Hydroxychloroquine, n (%) | 3 (7.9) | 3 (14.3) | 0.66 | |
| Remdesivir, n (%) | 1 (2.6) | 0 | 1 | |
| Lopinavir/ritonavir, n (%) | 7 (18.4) | 2 (9.5) | 0.47 | |
| Other, n (%) | 2 (5.3) | 0 | 0.53 | |
| Anti-inflammatory treatment, n (%) | 12 (31.6) | 3 (14.3) | 0.34 | |
| Dexamethasone, n (%) | 7 (18.4) | 2 (9.5) | 0.47 | |
| Anti-IL-1 therapy, n (%) | 1 (2.6) | 1 (4.8) | 1 | |
| Others, n (%) | 5 (13.2) | 1 (4.8) | 0.41 | |
| Use of adjunct measures and outcome | ||||
| Continuous neuromuscular blockers, n (%) | 29 (76.3) | 19 (90.5) | 0.30 | |
| Prone positioning, n (%) | 22 (57.9) | 19 (90.5) | 0.02 | |
| ECMO, n (%) | 2 (5.2) | 9 (42.9) | < 0.01 | |
| Vasopressive therapy, n (%) | 16 (42.1) | 18 (85.7) | < 0.01 | |
| Renal replacement therapy for AKI, n (%) | 5 (13.6) | 6 (28.6) | 0.17 | |
| Tracheotomy, n (%) | 12 (31.6) | 2 (9.5) | 0.11 | |
| Ventilator-associated pneumonia, n (%) | 19 (50) | 11 (52.4) | 1 | |
| Interregional transfer | 11 (28.9) | 1 (4.8) | 0.04 | |
| Initial management in Temporary ICU | 25 (65.8) | 12 (57.1) | 0.58 | |
Multivariate logistic regression of mortality in the whole cohort
| aOr | 95% CI | ||
|---|---|---|---|
| Age | 1.07 | 1.00-1.16 | 0.052 |
| SAPS-II (per 5 points) | 1.07 | 1.01-1.13 | 0.021 |
| ECMO | 27.2 | 3.64-369 | 0.004 |
| Temporary ICU | 1.37 | 0.32-6.67 | 0.7 |