| Literature DB >> 36187243 |
Zijian Deng1,2,3,4, Xiangkun Xu1,2,3, Iulian Iordachita5, Hamid Dehghani6, Bin Zhang7, John W Wong1, Ken Kang-Hsin Wang1,2,8.
Abstract
Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing in vivo soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and in vivo validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.Entities:
Year: 2022 PMID： 36187243 PMCID： PMC9484421 DOI： 10.1364/BOE.460737
Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.562