Literature DB >> 3618592

Genetic studies of human apolipoproteins. I. Polymorphism of apolipoprotein A-IV.

M I Kamboh, R E Ferrell.   

Abstract

Genetic polymorphism of human apolipoprotein A-IV has been detected by means of a simple and rapid one-dimensional isoelectric-focusing technique followed by immunoblotting. In plasma samples of normal U.S. whites and blacks, the specificity and sensitivity of the technique have been demonstrated to elucidate biochemical and genetic variation present in the APO A-IV molecule. Two common alleles, APO A-IV 1 and APO A-IV 2, have been observed with respective frequencies of .909 and .088 in whites and .961 and .035 in blacks. In addition, the products of two rare alleles designated APO A-IV 3 and APO A-IV 4 also have been observed. Family studies show autosomal codominant transmission of four alleles coded by a single structural locus.

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Year:  1987        PMID： 3618592      PMCID： PMC1684213     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  18 in total

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Authors:  P S Roheim; D Edelstein; G G Pinter
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

2.  The role of apolipoprotein A-IV in reverse cholesterol transport studied with cultured cells and liposomes derived from an ether analog of phosphatidylcholine.

Authors:  O Stein; Y Stein; M Lefevre; P S Roheim
Journal:  Biochim Biophys Acta       Date:  1986-08-14

3.  An apolipoprotein homolog of rat apolipoprotein A-IV in human plasma. Isolation and partial characterisation.

Authors:  U Beisiegel; G Utermann
Journal:  Eur J Biochem       Date:  1979-02-01

4.  Genetic variants of group A apolipoproteins. Rapid methods for screening and characterization without ultracentrifugation.

Authors:  G Utermann; G Feussner; G Franceschini; J Haas; A Steinmetz
Journal:  J Biol Chem       Date:  1982-01-10       Impact factor: 5.157

5.  Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Isolation and quantification.

Authors:  G Utermann; U Beisiegel
Journal:  Eur J Biochem       Date:  1979-09

6.  Human intestinal lipoproteins. Studies in chyluric subjects.

Authors:  P H Green; R M Glickman; C D Saudek; C B Blum; A R Tall
Journal:  J Clin Invest       Date:  1979-07       Impact factor: 14.808

7.  Apolipoprotein A-IV polymorphism in man.

Authors:  H J Menzel; P M Kövary; G Assmann
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

8.  Human apolipoprotein A-IV. Intestinal origin and distribution in plasma.

Authors:  P H Green; R M Glickman; J W Riley; E Quinet
Journal:  J Clin Invest       Date:  1980-04       Impact factor: 14.808

9.  Apolipoprotein localization and quantitation in the human intestine.

Authors:  P H Green; J H Lefkowitch; R M Glickman; J W Riley; E Quinet; C B Blum
Journal:  Gastroenterology       Date:  1982-12       Impact factor: 22.682

10.  One-step screening method for the polymorphism of apolipoproteins A-I, A-II, and A-IV.

Authors:  H J Menzel; R G Kladetzky; G Assmann
Journal:  J Lipid Res       Date:  1982-08       Impact factor: 5.922
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  5 in total

1.  Changes of genetic apolipoprotein phenotypes caused by liver transplantation. Implications for apolipoprotein synthesis.

Authors:  H G Kraft; H J Menzel; F Hoppichler; W Vogel; G Utermann
Journal:  J Clin Invest       Date:  1989-01       Impact factor: 14.808

2.  Human apolipoprotein A-IV polymorphism: frequency and effect on lipid and lipoprotein levels.

Authors:  H J Menzel; E Boerwinkle; S Schrangl-Will; G Utermann
Journal:  Hum Genet       Date:  1988-08       Impact factor: 4.132

3.  Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein.

Authors:  D J Rader; J Schäfer; P Lohse; B Verges; M Kindt; L A Zech; A Steinmetz; H B Brewer
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

4.  Genetic studies of human apolipoproteins. VII. Population distribution of polymorphisms of apolipoproteins A-I, A-II, A-IV, C-II, E, and H in Nigeria.

Authors:  B Sepehrnia; M I Kamboh; L L Adams-Campbell; M Nwankwo; R E Ferrell
Journal:  Am J Hum Genet       Date:  1988-12       Impact factor: 11.025

5.  Gene and gene-product variation in the apolipoprotein A-I/C-III/A-IV cluster in the Dogrib Indians of the Northwest Territories.

Authors:  S A Cole; E J Szathmary; R E Ferrell
Journal:  Am J Hum Genet       Date:  1989-06       Impact factor: 11.025
  5 in total

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