Sindhu Sivanandan1,2, Shuchita Gupta1,3, Tanushree Sahoo1,4, Chander Prakash Yadav1,5, Rohit Saxena6, Kapil Sikka7, Madhumati Bose1, Sheffali Gulati1, Atin Kumar8, Manisha Jana8, Savita Sapra1, Sumita Gupta1, M Jeeva Sankar9, Anu Thukral1, Sreenivas Vishnubhatla10, Vinod K Paul1,11, Ramesh Agarwal1. 1. Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 2. Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. 3. World Health Organization, New Delhi, India. 4. Department of Neonatology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. 5. National Institute of Malaria Research (NIMR), New Delhi, India. 6. Department of Ophthalmology, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 7. Department of ENT, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 8. Department of Radiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 9. Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. jeevasankar@gmail.com. 10. Department of Biostatistics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 11. Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), India and Member, NITI Aayog, New Delhi, India.
Abstract
OBJECTIVE: To study the growth and neurodevelopmental outcome of very and moderate preterm infants (VMPT) compared to term appropriate-for-age (term AGA) infants at 18-months corrected age. METHODS: This prospective cohort study enrolled consecutively born 212 VMPT infants and 250 term AGA controls delivered during study period. OUTCOME MEASURES: Major neurodevelopmental impairment (NDI) defined as any one of cerebral palsy, motor (MoDQ) or mental developmental quotient (MoDQ) <70 on Developmental Assessment Scale for Indian infants, visual or hearing impairment, or epilepsy, and growth outcomes. RESULTS: Among 195 VMPT and 240 term AGA infants who completed follow-up, the frequency of major NDI was 12.8% and 2.5% respectively (RR 5.1; 95% CI [2.13-12.19]). Major NDI was higher among infants <28 weeks gestation (39%) and birthweight <1000 grams (27%). A quarter of VMPT infants exhibited wasting and 18% stunting than 7% each among controls. CONCLUSION: VMPT infants had a higher frequency of major NDI and growth failure at 18-months.
OBJECTIVE: To study the growth and neurodevelopmental outcome of very and moderate preterm infants (VMPT) compared to term appropriate-for-age (term AGA) infants at 18-months corrected age. METHODS: This prospective cohort study enrolled consecutively born 212 VMPT infants and 250 term AGA controls delivered during study period. OUTCOME MEASURES: Major neurodevelopmental impairment (NDI) defined as any one of cerebral palsy, motor (MoDQ) or mental developmental quotient (MoDQ) <70 on Developmental Assessment Scale for Indian infants, visual or hearing impairment, or epilepsy, and growth outcomes. RESULTS: Among 195 VMPT and 240 term AGA infants who completed follow-up, the frequency of major NDI was 12.8% and 2.5% respectively (RR 5.1; 95% CI [2.13-12.19]). Major NDI was higher among infants <28 weeks gestation (39%) and birthweight <1000 grams (27%). A quarter of VMPT infants exhibited wasting and 18% stunting than 7% each among controls. CONCLUSION: VMPT infants had a higher frequency of major NDI and growth failure at 18-months.