Literature DB >> 36180715

A Method for Perfusion of Tissue-Isolated Human Tumor Xenografts in Nude Rats to Investigate the Oncostatic Role of the Physiological Nocturnal Melatonin Signal.

Robert T Dauchy1, Steven M Hill2, David E Blask2.   

Abstract

The tissue-isolated human tumor perfusion methodology enables the elucidation of physiological melatonin's oncostatic impact on cancer metabolism and physiology. Here we describe an apparatus and surgical technique for perfusing tissue-isolated human tumor xenografts in nude rats in situ that ensures continuous blood flow to and from the tissue. This system and methodology have proven quite successful in examining the receptor-mediated oncostatic effects of the physiological nocturnal melatonin signal on metabolism and physiology in a variety of epithelial and mesenchymal human tumors.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Melatonin; Nude rats; Tissue-isolated tumors; Tumor perfusions

Mesh：

Substances：

Year:  2022        PMID： 36180715     DOI： 10.1007/978-1-0716-2593-4_46

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  20 in total

1.  Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats.

Authors:  David E Blask; George C Brainard; Robert T Dauchy; John P Hanifin; Leslie K Davidson; Jean A Krause; Leonard A Sauer; Moises A Rivera-Bermudez; Margarita L Dubocovich; Samar A Jasser; Darin T Lynch; Mark D Rollag; Frederick Zalatan
Journal:  Cancer Res       Date:  2005-12-01       Impact factor: 12.701

2.  Human cancer xenograft perfusion in situ in rats: a new perfusion system that minimizes delivery time and maintains normal tissue physiology and responsiveness to growth-inhibitory agents.

Authors:  Erin M Dauchy; Robert T Dauchy; Leslie K Davidson; Darin T Lynch; Jean A Krause; Lia M Blue; Leonard A Sauer; David E Blask
Journal:  J Am Assoc Lab Anim Sci       Date:  2006-05       Impact factor: 1.232

3.  Amino acid, glucose, and lactic acid utilization in vivo by rat tumors.

Authors:  L A Sauer; J W Stayman; R T Dauchy
Journal:  Cancer Res       Date:  1982-10       Impact factor: 12.701

4.  Effects of Daytime Exposure to Light from Blue-Enriched Light-Emitting Diodes on the Nighttime Melatonin Amplitude and Circadian Regulation of Rodent Metabolism and Physiology.

Authors:  Robert T Dauchy; Melissa A Wren-Dail; Aaron E Hoffman; John P Hanifin; Benjamin Warfield; George C Brainard; Steven M Hill; Victoria P Belancio; Erin M Dauchy; David E Blask
Journal:  Comp Med       Date:  2016       Impact factor: 0.982

5.  Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression.

Authors:  David E Blask; Robert T Dauchy; Leonard A Sauer; Jean A Krause; George C Brainard
Journal:  Breast Cancer Res Treat       Date:  2003-06       Impact factor: 4.872

6.  Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids.

Authors:  Robert T Dauchy; Erin M Dauchy; Leslie K Davidson; Jean A Krause; Darin T Lynch; Paul C Tirrell; Robert P Tirrell; Leonard A Sauer; Peter Van der Riet; David E Blask
Journal:  Comp Med       Date:  2007-08       Impact factor: 0.982

7.  Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts.

Authors:  Robert T Dauchy; David E Blask; Erin M Dauchy; Leslie K Davidson; Paul C Tirrell; Michael W Greene; Robert P Tirrell; Cody R Hill; Leonard A Sauer
Journal:  J Pineal Res       Date:  2009-05-27       Impact factor: 13.007

8.  Preparation of "tissue-isolated" rat tumors for perfusion: a new surgical technique that preserves continuous blood flow.

Authors:  R T Dauchy; L A Sauer
Journal:  Lab Anim Sci       Date:  1986-12

9.  Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma.

Authors:  Lulu Mao; Robert T Dauchy; David E Blask; Erin M Dauchy; Lauren M Slakey; Samantha Brimer; Lin Yuan; Shulin Xiang; Adam Hauch; Kara Smith; Tripp Frasch; Victoria P Belancio; Melissa A Wren; Steven M Hill
Journal:  J Pineal Res       Date:  2015-12-23       Impact factor: 13.007

10.  Daytime Blue Light Enhances the Nighttime Circadian Melatonin Inhibition of Human Prostate Cancer Growth.

Authors:  Robert T Dauchy; Aaron E Hoffman; Melissa A Wren-Dail; John P Hanifin; Benjamin Warfield; George C Brainard; Shulin Xiang; Lin Yuan; Steven M Hill; Victoria P Belancio; Erin M Dauchy; Kara Smith; David E Blask
Journal:  Comp Med       Date:  2015-12       Impact factor: 0.982
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.