Zeki Aydin1, Murvet Yilmaz2, Murat Sipahioglu3, Erkan Dervisoglu4, Nihal Aydemir5, Sami Uzun6, Zulal Istemihan7, Oktay Unsal8, Erhan Tatar9, Haci Bayram Berktas10, Arzu Ozdemir2, Abdullah Sumnu11, Gizem Kumru12, Hakki Cetinkaya13, Sinan Kazan14, Ismail Kocyigit3, Cenk Gokalp15, Baris Hasbal16, Ayse Serra Artan17, Ruya Ozelsancak18, Dilek Taymez19, Serap Yadigar20, Selma Alagoz21, Bilal Burcak Aslan22, Selcuk Yaylaci23, Jabrayil Jabrayilov24, Kenan Turgutalp25, Belda Dursun26, Garip Sahin27. 1. Department of Nephrology, Darica Farabi Training and Research Hospital, University of Health Sciences, Fevziçakmak, Dr. Zeki Acar Ave. No: 62, 4170, Darica, Kocaeli, Turkey. zekiaydindr@yahoo.com. 2. Department of Nephrology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 3. Division of Nephrology, Department of Internal Medicine, Erciyes University School of Medicine, Kayseri, Turkey. 4. Division of Nephrology, Department of Internal Medicine, Kocaeli University School of Medicine, Kocaeli, Turkey. 5. Department of Nephrology, Ankara Numune Training and Research Hospital, University of Health Sciences, Ankara, Turkey. 6. Department of Nephrology, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 7. Division of Nephrology, Department of Internal Medicine, Istanbul University School of Medicine, Istanbul, Turkey. 8. Division of Nephrology, Department of Internal Medicine, Uludag University School of Medicine, Bursa, Turkey. 9. Department of Nephrology, Bozyaka Training and Research Hospital, University of Health Sciences, Izmir, Turkey. 10. Division of Nephrology, Department of Internal Medicine, Inonu University School of Medicine, Malatya, Turkey. 11. Department of Nephrology, Medipol University School of Medicine, Istanbul, Turkey. 12. Division of Nephrology, Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey. 13. Department of Nephrology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 14. Department of Nephrology, Afyonkarahisar School of Medicine, University of Health Sciences, Afyonkarahisar, Turkey. 15. Division of Nephrology, Department of Internal Medicine, Trakya University School of Medicine, Edirne, Turkey. 16. Department of Nephrology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 17. Division of Nephrology, Department of Internal Medicine, Bezm-I Alem Vakif University School of Medicine, Istanbul, Turkey. 18. Division of Nephrology, Department of Internal Medicine, Cukurova University School of Medicine, Adana, Turkey. 19. Department of Nephrology, Kocaeli State Hospital, Kocaeli, Turkey. 20. Department of Nephrology, Dr. Lutfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey. 21. Division of Nephrology, Department of Internal Medicine, Istanbul Cerrahpasa University School of Medicine, Istanbul, Turkey. 22. Department of Nephrology, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey. 23. Division of Nephrology, Department of Internal Medicine, Sakarya University School of Medicine, Sakarya, Turkey. 24. Division of Nephrology, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey. 25. Division of Nephrology, Department of Internal Medicine, Mersin University School of Medicine, Mersin, Turkey. 26. Division of Nephrology, Department of Internal Medicine, Pamukkale University School of Medicine, Denizli, Turkey. 27. Division of Nephrology, Department of Internal Medicine, Osmangazi University School of Medicine, Eskisehir, Turkey.
Abstract
PURPOSE: In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated. METHODS: Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented are cross-sectional and includes application data for the biopsy period. RESULTS: Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7 (0.6-1.0) mg/dl, mean eGFR was 104 ± 33 ml/min/1.73 m2 and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43, p < 0.001) interstitial inflammation (15 vs. 34, p < 0.001), interstitial fibrosis (20 vs. 31, p = 0.001, vascular changes (10 vs. 25, p < 0.001) and tubular atrophy (18 vs. 30, p < 0.001) were found to be significantly higher in Group B. There was no difference in immunofluorescent staining properties between the two groups. CONCLUSION: Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.
PURPOSE: In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated. METHODS: Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented are cross-sectional and includes application data for the biopsy period. RESULTS: Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7 (0.6-1.0) mg/dl, mean eGFR was 104 ± 33 ml/min/1.73 m2 and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43, p < 0.001) interstitial inflammation (15 vs. 34, p < 0.001), interstitial fibrosis (20 vs. 31, p = 0.001, vascular changes (10 vs. 25, p < 0.001) and tubular atrophy (18 vs. 30, p < 0.001) were found to be significantly higher in Group B. There was no difference in immunofluorescent staining properties between the two groups. CONCLUSION: Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.
Authors: Savas Ozturk; Abdullah Sumnu; Nurhan Seyahi; Mustafa Gullulu; Murat Sipahioglu; Serra Artan; Zerrin Bicik; Sim Kutlay; Mustafa Keles; Deren Oygar; Ali Riza Odabas; Mansur Kayatas; Belda Dursun; Hayriye Sayarlioglu; Sinan Trablus; Dilek Guven Taymez; Ali Abbas Ozdemir; Gulizar Manga Sahin; Bulent Altun; Alper Azak; Lutfullah Altintepe; Gultekin Suleymanlar; Mehmet Koc; Yilmaz Selcuk; Rumeyza Kazancioglu; Reha Erkoc; Meltem Gursu; Mehmet Kucuk; Selma Alagoz Akcaoglu; Abdulmecid Yıldız; Aydin Unal; Ozger Akarsu; Kenan Ates; Erdem Cankaya; Aydin Turkmen Journal: Int Urol Nephrol Date: 2014-09-30 Impact factor: 2.370
Authors: Andrew S Levey; Lesley A Stevens; Christopher H Schmid; Yaping Lucy Zhang; Alejandro F Castro; Harold I Feldman; John W Kusek; Paul Eggers; Frederick Van Lente; Tom Greene; Josef Coresh Journal: Ann Intern Med Date: 2009-05-05 Impact factor: 25.391
Authors: Marco Fiorentino; Davide Bolignano; Vladimir Tesar; Anna Pisano; Wim Van Biesen; Graziella D'Arrigo; Giovanni Tripepi; Loreto Gesualdo Journal: Am J Nephrol Date: 2016-02-05 Impact factor: 3.754
Authors: Sarah E Panzer; Jennifer Laskowski; Brandon Renner; Liudmila Kulik; Danica Ljubanovic; Kendra M Huber; Weixiong Zhong; Matthew C Pickering; V Michael Holers; Joshua M Thurman Journal: Kidney Int Date: 2015-05-06 Impact factor: 10.612