Jing Liu1, Jun Yu1, Hong Biao Liu1, Qiong Yao1, Ying Zhang2. 1. Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China. 2. Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China. zhangying5401@zju.edu.cn.
Abstract
BACKGROUND: Recent studies suggest that selective serotonin reuptake inhibitors (SSRIs) and exposure therapies have been used to reduced footshock-induced posttraumatic stress disorder (PTSD) symptoms. However, the therapeutic effect of the combination of SSRIs treatment with exposure therapy remains a matter of debate. This study aimed to evaluate these therapeutic effect through the behavioural and the neuroimaging changes by positron emission tomography (PET) in model rats. METHODS: Pavlovian fear conditioning paradigm to establish model rats, and serial PET imaging with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was performed during the control, fear-conditioning, and extinction-retrieval phases. The expression of c-Fos was used to identify neural activity. RESULTS: We report that fear conditioning increased glucose metabolism in the right amygdala and left primary visual cortex but decreased glucose metabolism in the left primary somatosensory cortex. After extinction retrieval, there was increased [18F]FDG uptake in the left striatum, left cochlear nucleus and right primary visual cortex but decreased uptake in the anterior cingulate cortex in the extinction group. Fluoxetine increased [18F]FDG uptake in the left hippocampus and right primary visual cortex but decreased uptake in the bilateral primary somatosensory cortex, left primary/secondary motor cortex and cuneiform nucleus. The combined therapy increased [18F]FDG uptake in the left hippocampus, left striatum, right insular cortex, left posterior parietal cortex, and right secondary visual cortex but reduced uptake in the cerebellar lobule. c-Fos expression in the hippocampal dentate gyrus and anterior cingulate cortex in the fluoxetine and combined groups was significantly higher than that in the extinction group, with no significant difference between the two groups. CONCLUSIONS: Chronic fluoxetine enhanced the effects of extinction training in a rat model of PTSD. In vivo PET imaging may provide a promising approach for evaluation chronic fluoxetine treatment of PTSD.
BACKGROUND: Recent studies suggest that selective serotonin reuptake inhibitors (SSRIs) and exposure therapies have been used to reduced footshock-induced posttraumatic stress disorder (PTSD) symptoms. However, the therapeutic effect of the combination of SSRIs treatment with exposure therapy remains a matter of debate. This study aimed to evaluate these therapeutic effect through the behavioural and the neuroimaging changes by positron emission tomography (PET) in model rats. METHODS: Pavlovian fear conditioning paradigm to establish model rats, and serial PET imaging with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) was performed during the control, fear-conditioning, and extinction-retrieval phases. The expression of c-Fos was used to identify neural activity. RESULTS: We report that fear conditioning increased glucose metabolism in the right amygdala and left primary visual cortex but decreased glucose metabolism in the left primary somatosensory cortex. After extinction retrieval, there was increased [18F]FDG uptake in the left striatum, left cochlear nucleus and right primary visual cortex but decreased uptake in the anterior cingulate cortex in the extinction group. Fluoxetine increased [18F]FDG uptake in the left hippocampus and right primary visual cortex but decreased uptake in the bilateral primary somatosensory cortex, left primary/secondary motor cortex and cuneiform nucleus. The combined therapy increased [18F]FDG uptake in the left hippocampus, left striatum, right insular cortex, left posterior parietal cortex, and right secondary visual cortex but reduced uptake in the cerebellar lobule. c-Fos expression in the hippocampal dentate gyrus and anterior cingulate cortex in the fluoxetine and combined groups was significantly higher than that in the extinction group, with no significant difference between the two groups. CONCLUSIONS: Chronic fluoxetine enhanced the effects of extinction training in a rat model of PTSD. In vivo PET imaging may provide a promising approach for evaluation chronic fluoxetine treatment of PTSD.
Authors: Andrea Cipriani; Taryn Williams; Adriani Nikolakopoulou; Georgia Salanti; Anna Chaimani; Jonathan Ipser; Phil J Cowen; John R Geddes; Dan J Stein Journal: Psychol Med Date: 2017-12-19 Impact factor: 7.723
Authors: Jonathan I Bisson; Lucy Berliner; Marylene Cloitre; David Forbes; Tine K Jensen; Catrin Lewis; Candice M Monson; Miranda Olff; Stephen Pilling; David S Riggs; Neil P Roberts; Francine Shapiro Journal: J Trauma Stress Date: 2019-07-08
Authors: Amy S Garrett; Victor Carrion; Hilit Kletter; Asya Karchemskiy; Carl F Weems; Allan Reiss Journal: Depress Anxiety Date: 2012-05 Impact factor: 6.505
Authors: K C Koenen; A Ratanatharathorn; L Ng; K A McLaughlin; E J Bromet; D J Stein; E G Karam; A Meron Ruscio; C Benjet; K Scott; L Atwoli; M Petukhova; C C W Lim; S Aguilar-Gaxiola; A Al-Hamzawi; J Alonso; B Bunting; M Ciutan; G de Girolamo; L Degenhardt; O Gureje; J M Haro; Y Huang; N Kawakami; S Lee; F Navarro-Mateu; B-E Pennell; M Piazza; N Sampson; M Ten Have; Y Torres; M C Viana; D Williams; M Xavier; R C Kessler Journal: Psychol Med Date: 2017-04-07 Impact factor: 7.723