Literature DB >> 36176648

KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.

Karl A Nath1, Raman Deep Singh1, Anthony J Croatt1, Allan W Ackerman1, Joseph P Grande2, Khasayarsha Khazaie3, Y Eugene Chen4, Jifeng Zhang4.   

Abstract

Discovering new nephroprotectants may provide therapeutic strategies in AKI.This study provides the first evidence that KLF11, a member of the Krüppel-like factor (KLF) family of proteins, protects against AKI.In the absence of KLF11, exaggerated induction of endothelin-1 and IL-6 occurs after ischemic renal injury and may contribute to worse AKI.
Copyright © 2022 by the American Society of Nephrology.

Entities:  

Keywords:  IL-6; KLF11; acute kidney injury; acute kidney injury and ICU nephrology; basic science; endothelin-1; heme oxygenase-1; protectant; reperfusion injury

Mesh：

Substances：

Year:  2022        PMID： 36176648      PMCID： PMC9416845          DOI： 10.34067/KID.0002272022

Source DB:  PubMed          Journal:  Kidney360        ISSN： 2641-7650


  17 in total

1.  Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure.

Authors:  Prasad R Konkalmatt; Laureano D Asico; Yanrong Zhang; Yu Yang; Cinthia Drachenberg; Xiaoxu Zheng; Fei Han; Pedro A Jose; Ines Armando
Journal:  JCI Insight       Date:  2016-06-02

Review 2.  Role of endothelin and endothelin receptor antagonists in renal disease.

Authors:  W Neuhofer; D Pittrow
Journal:  Eur J Clin Invest       Date:  2006-09       Impact factor: 4.686

Review 3.  Krüppel-like factors and vascular wall homeostasis.

Authors:  Yanbo Fan; Haocheng Lu; Wenying Liang; Wenting Hu; Jifeng Zhang; Y Eugene Chen
Journal:  J Mol Cell Biol       Date:  2017-10-01       Impact factor: 6.216

Review 4.  The critical role of Krüppel-like factors in kidney disease.

Authors:  Sandeep K Mallipattu; Chelsea C Estrada; John C He
Journal:  Am J Physiol Renal Physiol       Date:  2016-11-16

5.  Fenofibrate inhibits endothelin-1 expression by peroxisome proliferator-activated receptor α-dependent and independent mechanisms in human endothelial cells.

Authors:  Corine Glineur; Barbara Gross; Bernadette Neve; Corinne Rommens; Gerard T Chew; Françoise Martin-Nizard; Fernando Rodríguez-Pascual; Santiago Lamas; Gerald F Watts; Bart Staels
Journal:  Arterioscler Thromb Vasc Biol       Date:  2013-01-17       Impact factor: 8.311

6.  Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway.

Authors:  Yanbo Fan; Yanhong Guo; Jifeng Zhang; Malayannan Subramaniam; Chao-Zhong Song; Raul Urrutia; Y Eugene Chen
Journal:  Arterioscler Thromb Vasc Biol       Date:  2012-10-04       Impact factor: 8.311

Review 7.  Heme oxygenase-1 and acute kidney injury.

Authors:  Karl A Nath
Journal:  Curr Opin Nephrol Hypertens       Date:  2014-01       Impact factor: 2.894

8.  Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines.

Authors:  Timothy E Cullingford; Matthew J Butler; Andrew K Marshall; El Li Tham; Peter H Sugden; Angela Clerk
Journal:  Biochim Biophys Acta       Date:  2008-03-25

Review 9.  Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update.

Authors:  Hua Su; Chun-Tao Lei; Chun Zhang
Journal:  Front Immunol       Date:  2017-04-21       Impact factor: 7.561

Review 10.  Krϋppel-like factors (KLFs) in renal physiology and disease.

Authors:  Madhavi J Rane; Yuguang Zhao; Lu Cai
Journal:  EBioMedicine       Date:  2019-01-17       Impact factor: 8.143
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.