BACKGROUND: Histiocytic and dendritic cell neoplasms (HDCNs) represent very rare tumors, which have been the subject of debate during the last few years. OBJECTIVES: We aimed to provide a comprehensive review of the subject. MATERIALS AND METHODS: The experience gained by the authors in large international studies and as a national reference center has been summarized to highlight the characteristics of each entity. RESULTS: The clinical, morphologic, phenotypic, and molecular data of the different entities included under the heading of HDCNs are extensively discussed. CONCLUSION: Currently, HDCNs are classified in the group of orphan diseases for which a standardized therapy is lacking. An international registry would facilitate expansion and dissemination of knowledge of these diseases and improve their treatment.
BACKGROUND: Histiocytic and dendritic cell neoplasms (HDCNs) represent very rare tumors, which have been the subject of debate during the last few years. OBJECTIVES: We aimed to provide a comprehensive review of the subject. MATERIALS AND METHODS: The experience gained by the authors in large international studies and as a national reference center has been summarized to highlight the characteristics of each entity. RESULTS: The clinical, morphologic, phenotypic, and molecular data of the different entities included under the heading of HDCNs are extensively discussed. CONCLUSION: Currently, HDCNs are classified in the group of orphan diseases for which a standardized therapy is lacking. An international registry would facilitate expansion and dissemination of knowledge of these diseases and improve their treatment.
Authors: Laurence de Leval; Ash A Alizadeh; P Leif Bergsagel; Elias Campo; Andrew John Davies; Ahmet Dogan; Jude Fitzgibbon; Steven M Horwitz; Ari M Melnick; William George Morice; Ryan D Morin; Bertrand Nadel; Stefano A Pileri; Richard Rosenquist; Davide Rossi; Itziar Salaverria; Christian Steidl; Steven P Treon; Andrew D Zelenetz; Ranjana Advani; Carl E Allen; Stephen M Ansell; Wing C Chan; James R Cook; Lucy B Cook; Francesco d'Amore; Stefan Dirnhofer; Martin Dreyling; Kieron Dunleavy; Andrew Feldman; Falko Fend; Philippe Gaulard; Paolo Ghia; John G Gribben; Olivier Hermine; Daniel J Hodson; Eric D Hsi; Giorgio Ga Inghirami; Elaine S Jaffe; Kennosuke Karube; Keisuke Kataoka; Wolfram Klapper; Won Seog Kim; Rebecca L King; Young Hyeh Ko; Ann S LaCasce; Georg Lenz; Iñaki Martin-Subero; Miguel A Piris; Stefania Pittaluga; Laura Pasqualucci; Leticia Quintanilla-Martinez; Scott J Rodig; Andreas Rosenwald; Gilles A Salles; Jesus San-Miguel; Kerry J Savage; Laurie H Sehn; Gianpietro Semenzato; Louis M Staudt; Steven Howard Swerdlow; Constantine S Tam; Judith Trotman; Julie Vose; Oliver Weigert; Wyndham H Wilson; Jane N Winter; Catherine J Wu; Pier Luigi Zinzani; Emanuele Zucca; Adam Bagg; David W W Scott Journal: Blood Date: 2022-08-24 Impact factor: 25.476