Literature DB >> 36175641

Synthesis and Neuraminidase Inhibitory Activity of Sialic Acid Analogues with Fluoro, Phosphono, and Sulfo Functionalities.

Christopher J Vavricka1, Nongluk Sriwilaijaroen2,3, Yasuo Suzuki3, Hiromasa Kiyota4.   

Abstract

Methods to synthesize influenza virus inhibitors with fluoro, phosphono, and/or sulfo functional groups are described. The resulting sialic acid analogues are produced from the natural substrate N-acetylneuraminic acid as starting material. Fluorescent assay methods for inhibition of influenza neuraminidase and virus proliferation are also provided.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Fluoro-sialic acids; Influenza virus; Neuraminidase; Phosphono-sialic acids; Sulfo-sialic acids

Mesh：

Substances：

Year:  2022        PMID： 36175641     DOI： 10.1007/978-1-0716-2635-1_20

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  2 in total

1.  Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.

Authors:  Qing Li; Jianxun Qi; Yan Wu; Hiromasa Kiyota; Kosuke Tanaka; Yoshitomo Suhara; Hiroshi Ohrui; Yasuo Suzuki; Christopher J Vavricka; George F Gao
Journal:  J Virol       Date:  2013-07-03       Impact factor: 5.103

2.  Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.

Authors:  Christopher J Vavricka; Yue Liu; Hiromasa Kiyota; Nongluk Sriwilaijaroen; Jianxun Qi; Kosuke Tanaka; Yan Wu; Qing Li; Yan Li; Jinghua Yan; Yasuo Suzuki; George F Gao
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.