Literature DB >> 36173554

Role of IL-22 in intestinal microenvironment and potential targeted therapy through diet.

Peiying Wang1, Wing Keung Chan2, Jiming Wang3, Zhouxin Yang4, Youwei Wang5.   

Abstract

IL-22 is a type 2 receptor cytokine in IL-10 family. IL-22 is usually secreted by innate and adaptive immune cells and takes its effects on non-hematopoietic cells. Through activate STAT3 pathway, IL-22 plays an important role in infection clearance and tissue regeneration, which is critical for barrier integrate and homeostasis. Abnormal activation of IL-22 signal was observed in inflammation diseases, autoimmune diseases, and cancers. We review the recent discoveries about the mechanism and regulation of IL-22 signal pathway from the perspective of intestinal micro-environment. Diet-based IL-22 target therapeutic strategies and their potential clinical significance will also be discussed.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Cytokines; Innate lymphoid cells; Interleukin-22; Intestinal immunity

Year:  2022        PMID： 36173554     DOI： 10.1007/s12026-022-09325-5

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   4.505


  81 in total

1.  Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9.

Authors:  L Dumoutier; J Louahed; J C Renauld
Journal:  J Immunol       Date:  2000-02-15       Impact factor: 5.422

2.  IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.

Authors:  Stephan Brand; Julia Dambacher; Florian Beigel; Kathrin Zitzmann; Malte H J Heeg; Thomas S Weiss; Thomas Prüfer; Torsten Olszak; Christian J Steib; Martin Storr; Burkhard Göke; Helmut Diepolder; Manfred Bilzer; Wolfgang E Thasler; Christoph J Auernhammer
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2007-01-04       Impact factor: 4.052

3.  IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.

Authors:  Shean J Aujla; Yvonne R Chan; Mingquan Zheng; Mingjian Fei; David J Askew; Derek A Pociask; Todd A Reinhart; Florencia McAllister; Jennifer Edeal; Kristi Gaus; Shahid Husain; James L Kreindler; Patricia J Dubin; Joseph M Pilewski; Mike M Myerburg; Carol A Mason; Yoichiro Iwakura; Jay K Kolls
Journal:  Nat Med       Date:  2008-02-10       Impact factor: 53.440

4.  Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine.

Authors:  Hidekazu Ikeuchi; Takashi Kuroiwa; Noriyuki Hiramatsu; Yoriaki Kaneko; Keiju Hiromura; Kazue Ueki; Yoshihisa Nojima
Journal:  Arthritis Rheum       Date:  2005-04

5.  Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

Authors:  M H Xie; S Aggarwal; W H Ho; J Foster; Z Zhang; J Stinson; W I Wood; A D Goddard; A L Gurney
Journal:  J Biol Chem       Date:  2000-10-06       Impact factor: 5.157

6.  Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts.

Authors:  Akira Andoh; Zhuobin Zhang; Osamu Inatomi; Sanae Fujino; Yasuyuki Deguchi; Yoshio Araki; Tomoyuki Tsujikawa; Katsuyuki Kitoh; Shokei Kim-Mitsuyama; Atsushi Takayanagi; Nobuyoshi Shimizu; Yoshihide Fujiyama
Journal:  Gastroenterology       Date:  2005-09       Impact factor: 22.682

7.  IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

Authors:  Ken Sugimoto; Atsuhiro Ogawa; Emiko Mizoguchi; Yasuyo Shimomura; Akira Andoh; Atul K Bhan; Richard S Blumberg; Ramnik J Xavier; Atsushi Mizoguchi
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

8.  Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

Authors:  Diane Lejeune; Laure Dumoutier; Stefan Constantinescu; Wiebe Kruijer; Jan Jacob Schuringa; Jean-Christophe Renauld
Journal:  J Biol Chem       Date:  2002-06-26       Impact factor: 5.157

9.  IL-22 increases the innate immunity of tissues.

Authors:  Kerstin Wolk; Stefanie Kunz; Ellen Witte; Markus Friedrich; Khusru Asadullah; Robert Sabat
Journal:  Immunity       Date:  2004-08       Impact factor: 31.745

10.  Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.

Authors:  Spencer C Liang; Xiang-Yang Tan; Deborah P Luxenberg; Riyez Karim; Kyriaki Dunussi-Joannopoulos; Mary Collins; Lynette A Fouser
Journal:  J Exp Med       Date:  2006-09-18       Impact factor: 14.307
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