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Literature DB >> 361685

Isolation and characterization of an actinomycin D-sensitive mutant of Saccharomyces cerevisiae.

Abstract

A single mutation in Saccharomyces cerevisiae conferred sensitivity to low concentrations of actinomycin D. Treatment with actinomycin D preferentially inhibited synthesis of rRNA's. Residual rRNA synthesized was processed normally. Total protein synthesis and inducibility of the enzyme maltase were relatively unaffected at concentrations of actinomycin D which severely inhibited rRNA synthesis.

Entities: Chemical Species

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Year: 1978 PMID： 361685 PMCID： PMC218643 DOI： 10.1128/jb.136.1.142-147.1978

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

22 in total

1. Chromosome Mapping in Saccharomyces: Centromere-Linked Genes.

Authors: D C Hawthorne; R K Mortimer
Journal: Genetics Date: 1960-08 Impact factor: 4.562

2. Biochemical Mutants in the Smut Fungus Ustilago Maydis.

Authors: D D Perkins
Journal: Genetics Date: 1949-09 Impact factor: 4.562

3. The effects of inhibitors of RNA and DNA synthesis on protein synthesis and polysome levels in mouse L-cells.

Authors: N Craig
Journal: J Cell Physiol Date: 1973-10 Impact factor: 6.384

4. Selection of yeast mutants constitutive for maltase synthesis.

Authors: R Needleman; N R Eaton
Journal: Mol Gen Genet Date: 1974

5. Destructive processing of the 45-S ribosomal precursor in the presence of 5-azacytidine.

Authors: M Reichman; D Karlan; S Penman
Journal: Biochim Biophys Acta Date: 1973-02-23

6. Characterization of messenger RNA in protoplasts of Saccharomyces carlsbergensis.

Authors: R Hartlief; V V Koningsberger
Journal: Biochim Biophys Acta Date: 1968-09-24

7. Degradation of ribosomal precursor and polyadenylic acid-containing ribonucleic acids in Saccharomyces cerebisiae caused by actinomycin D.

Authors: L W Waltschewa; P V Venkov; B B Stoyanova; A A Hadjiolov
Journal: Arch Biochem Biophys Date: 1976-10 Impact factor: 4.013

Isolation and characterization of an actinomycin D-sensitive mutant of Saccharomyces cerevisiae.

1. Chromosome Mapping in Saccharomyces: Centromere-Linked Genes.

2. Biochemical Mutants in the Smut Fungus Ustilago Maydis.

3. The effects of inhibitors of RNA and DNA synthesis on protein synthesis and polysome levels in mouse L-cells.

4. Selection of yeast mutants constitutive for maltase synthesis.

5. Destructive processing of the 45-S ribosomal precursor in the presence of 5-azacytidine.

6. Characterization of messenger RNA in protoplasts of Saccharomyces carlsbergensis.

7. Degradation of ribosomal precursor and polyadenylic acid-containing ribonucleic acids in Saccharomyces cerebisiae caused by actinomycin D.

Review 8. Maturation of ribosomal ribonucleic acids and the biogenesis of ribosomes.

9. Resolution of multiple ribonucleic acid species by polyacrylamide gel electrophoresis.

10. Noncoordinated transcription in the absence of protein synthesis in yeast.

1. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.