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Literature DB >> 3616624

Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family.

E H Chang, K F Pirollo, Z Q Zou, H Y Cheung, E L Lawler, R Garner, E White, W B Bernstein, J W Fraumeni, W A Blattner.

Abstract

Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-1 gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying the familial predisposition to a variety of cancers.

Entities: Disease Gene

Mesh：

Year: 1987 PMID： 3616624 DOI： 10.1126/science.3616624

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

10 in total

Review 1. Genetic and epigenetic features in radiation sensitivity. Part II: implications for clinical practice and radiation protection.

Authors: Michel H Bourguignon; Pablo A Gisone; Maria R Perez; Severino Michelin; Diana Dubner; Marina Di Giorgio; Edgardo D Carosella
Journal: Eur J Nucl Med Mol Imaging Date: 2005-03 Impact factor: 9.236

2. Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells.

Authors: A M Pfeifer; G E Mark; L Malan-Shibley; S Graziano; P Amstad; C C Harris
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205

3. Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

Authors: V P Stanton; D W Nichols; A P Laudano; G M Cooper
Journal: Mol Cell Biol Date: 1989-02 Impact factor: 4.272

4. p53 deficiency does not affect the accumulation of point mutations in a transgene target.

Authors: A T Sands; M B Suraokar; A Sanchez; J E Marth; L A Donehower; A Bradley
Journal: Proc Natl Acad Sci U S A Date: 1995-08-29 Impact factor: 11.205

5. Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells.

Authors: D M O'Rourke; G D Kao; N Singh; B W Park; R J Muschel; C J Wu; M I Greene
Journal: Proc Natl Acad Sci U S A Date: 1998-09-01 Impact factor: 11.205

10. Abnormal pattern of post-gamma-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome.

Authors: R Mirzayans; R A Aubin; W Bosnich; W A Blattner; M C Paterson
Journal: Br J Cancer Date: 1995-06 Impact factor: 7.640

10 in total

Oncogenes in radioresistant, noncancerous skin fibroblasts from a cancer-prone family.

Review 1. Genetic and epigenetic features in radiation sensitivity. Part II: implications for clinical practice and radiation protection.

2. Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of simian virus 40 large tumor antigen-immortalized human bronchial epithelial cells.

3. Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

4. p53 deficiency does not affect the accumulation of point mutations in a transgene target.

5. Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells.

6. Neoplastic transformation of breast epithelial cells by genotoxic stress.

7. p53 mutations increase resistance to ionizing radiation.

8. Activated protooncogenes in human lung tumors from smokers.

9. Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.

10. Abnormal pattern of post-gamma-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome.