Tilmann Kramer1,2, Paul Brinkkoetter3,4,5, Stephan Rosenkranz6,3,5. 1. Klinik III Für Innere Medizin, Herzzentrum Der Universität Zu Köln, Köln, Germany. tilmann.kramer@uk-koeln.de. 2. Cologne Cardiovascular Research Center (CCRC), Klinikum Der Universität Zu Köln, Köln, Germany. tilmann.kramer@uk-koeln.de. 3. Cologne Cardiovascular Research Center (CCRC), Klinikum Der Universität Zu Köln, Köln, Germany. 4. Klinik II Für Innere Medizin, Nephrologie, Universität Zu Köln, Köln, Germany. 5. Center for Molecular Medicine Cologne (CMMC), Universität Zu Köln, Köln, Germany. 6. Klinik III Für Innere Medizin, Herzzentrum Der Universität Zu Köln, Köln, Germany.
Abstract
PURPOSE OF REVIEW: Since CRS is critically dependent on right heart function and involved in interorgan crosstalk, assessment and monitoring of both right heart and kidney function are of utmost importance for clinical outcomes. This systematic review aims to comprehensively report on novel diagnostic and therapeutic paradigms that are gaining importance for the clinical management of the growing heart failure population suffering from CRS. RECENT FINDINGS: Cardiorenal syndrome (CRS) in patients with heart failure is associated with poor outcome. Although systemic venous congestion and elevated central venous pressure have been recognized as main contributors to CRS, they are often neglected in clinical practice. The delicate hemodynamic balance in CRS is particularly determined by the respective status of the right heart. The consideration of hemodynamic and CRS profiles is advantageous in tailoring treatment for better preservation of renal function. Assessment and monitoring of right heart and renal function by known and emerging tools like renal Doppler ultrasonography or new biomarkers may have direct clinical implications.
PURPOSE OF REVIEW: Since CRS is critically dependent on right heart function and involved in interorgan crosstalk, assessment and monitoring of both right heart and kidney function are of utmost importance for clinical outcomes. This systematic review aims to comprehensively report on novel diagnostic and therapeutic paradigms that are gaining importance for the clinical management of the growing heart failure population suffering from CRS. RECENT FINDINGS: Cardiorenal syndrome (CRS) in patients with heart failure is associated with poor outcome. Although systemic venous congestion and elevated central venous pressure have been recognized as main contributors to CRS, they are often neglected in clinical practice. The delicate hemodynamic balance in CRS is particularly determined by the respective status of the right heart. The consideration of hemodynamic and CRS profiles is advantageous in tailoring treatment for better preservation of renal function. Assessment and monitoring of right heart and renal function by known and emerging tools like renal Doppler ultrasonography or new biomarkers may have direct clinical implications.
Authors: Wilfried Mullens; Zuheir Abrahams; Hadi N Skouri; Gary S Francis; David O Taylor; Randall C Starling; Emil Paganini; W H Wilson Tang Journal: J Am Coll Cardiol Date: 2008-01-22 Impact factor: 24.094
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Authors: Wilfried Mullens; Pieter Martens; Jeffrey M Testani; W H Wilson Tang; Hadi Skouri; Frederik H Verbrugge; Marat Fudim; Massimo Iacoviello; Jennifer Franke; Andreas J Flammer; Alberto Palazzuoli; Paola Morejon Barragan; Thomas Thum; Marta Cobo Marcos; Òscar Miró; Patrick Rossignol; Marco Metra; Johan Lassus; Francesco Orso; Ewa A Jankowska; Ovidiu Chioncel; Davor Milicic; Loreena Hill; Petar Seferovic; Giuseppe Rosano; Andrew Coats; Kevin Damman Journal: Eur J Heart Fail Date: 2022-03-27 Impact factor: 17.349
Authors: Wilfried Mullens; Zuheir Abrahams; Gary S Francis; George Sokos; David O Taylor; Randall C Starling; James B Young; W H Wilson Tang Journal: J Am Coll Cardiol Date: 2009-02-17 Impact factor: 24.094
Authors: Kevin Damman; Vincent M van Deursen; Gerjan Navis; Adriaan A Voors; Dirk J van Veldhuisen; Hans L Hillege Journal: J Am Coll Cardiol Date: 2009-02-17 Impact factor: 24.094
Authors: Claudio Ronco; Peter McCullough; Stefan D Anker; Inder Anand; Nadia Aspromonte; Sean M Bagshaw; Rinaldo Bellomo; Tomas Berl; Ilona Bobek; Dinna N Cruz; Luciano Daliento; Andrew Davenport; Mikko Haapio; Hans Hillege; Andrew A House; Nevin Katz; Alan Maisel; Sunil Mankad; Pierluigi Zanco; Alexandre Mebazaa; Alberto Palazzuoli; Federico Ronco; Andrew Shaw; Geoff Sheinfeld; Sachin Soni; Giorgio Vescovo; Nereo Zamperetti; Piotr Ponikowski Journal: Eur Heart J Date: 2009-12-25 Impact factor: 29.983