Gabriela Ribeiro de Araújo1, Ana Luísa Morais-Perdigão1, Cinthia Verónica Bardález Lopez de Cáceres2, Márcio Ajudarte Lopes2, José Manuel Aguirre-Urizar3, Roman Carlos4, Elena María José Román Tager2,4, Willie F P van Heerden5, Liam Robinson5, Hélder Antônio Rebelo Pontes6, Bruno Augusto Benevenuto de Andrade7, Ciro Dantas Soares8, Ricardo Santiago Gomez1, Felipe Paiva Fonseca9,10,11. 1. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, 6627, Brazil. 2. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. 3. Department of Stomatology II, University of the Basque Country (UPV-EHU), Bizkaia, Spain. 4. Centro Clínico de Cabeza Y Cuello, Guatemala City, Guatemala. 5. Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa. 6. Service of Oral Pathology, João de Barros, Barreto University Hospital, Federal University of Pará, Belém, Brazil. 7. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 8. Private Pathology Service, Getúlio Sales Diagnósticos, Natal, RN, Brasil. 9. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, Belo Horizonte, 6627, Brazil. felipepfonseca@hotmail.com. 10. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. felipepfonseca@hotmail.com. 11. Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa. felipepfonseca@hotmail.com.
Abstract
BACKGROUND: Lymphomas affecting the sublingual glands are extremely rare and very few case reports are currently available. Therefore, the aim of the current study is to describe the clinicopathological features of a series of lymphomas involving the sublingual glands. METHODS: Cases diagnosed in four pathology services were assessed and the formalin-fixed paraffin-embedded tissue blocks were retrieved for diagnosis confirmation. Clinical data were obtained from patients' medical files. RESULTS: We obtained seven cases of lymphomas in the sublingual glands, representing two follicular lymphomas, two diffuse large B cell lymphomas not otherwise specified (DLBCL NOS), two extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphomas) and one mantle cell lymphoma (MCL). In all cases the tumor cells infiltrated the glandular parenchyma, although in two of them the neoplastic cells were located more superficially and permeated the glandular acini and ducts. Clinically, the tumors presented as asymptomatic nodules and two patients (affected by DLBCL NOS and MCL) died, while the other five patients remained alive at last follow-up. CONCLUSION: Lymphomas affecting the sublingual glands are usually of the mature B cell lineage, often represent low-grade subtypes and may clinically resemble other more common lesions in the floor of the mouth like salivary gland tumors.
BACKGROUND: Lymphomas affecting the sublingual glands are extremely rare and very few case reports are currently available. Therefore, the aim of the current study is to describe the clinicopathological features of a series of lymphomas involving the sublingual glands. METHODS: Cases diagnosed in four pathology services were assessed and the formalin-fixed paraffin-embedded tissue blocks were retrieved for diagnosis confirmation. Clinical data were obtained from patients' medical files. RESULTS: We obtained seven cases of lymphomas in the sublingual glands, representing two follicular lymphomas, two diffuse large B cell lymphomas not otherwise specified (DLBCL NOS), two extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphomas) and one mantle cell lymphoma (MCL). In all cases the tumor cells infiltrated the glandular parenchyma, although in two of them the neoplastic cells were located more superficially and permeated the glandular acini and ducts. Clinically, the tumors presented as asymptomatic nodules and two patients (affected by DLBCL NOS and MCL) died, while the other five patients remained alive at last follow-up. CONCLUSION: Lymphomas affecting the sublingual glands are usually of the mature B cell lineage, often represent low-grade subtypes and may clinically resemble other more common lesions in the floor of the mouth like salivary gland tumors.
Authors: Carla Isabelly Rodrigues-Fernandes; Lucas Lacerda de Souza; Sara Ferreira Dos Santos-Costa; Hélder Antônio Rebelo Pontes; Oslei Paes de Almeida; Pablo Agustin Vargas; Javier Rendón Henao; Siavash Rahimi; Peter A Brennan; Felipe Paiva Fonseca Journal: J Oral Pathol Med Date: 2018-12-01 Impact factor: 4.253
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