Literature DB >> 3615986

Multistage model interpretation of additive and multiplicative carcinogenic effects.

H J Gibb, C W Chen.   

Abstract

Under the assumption of multistage carcinogenesis, a multiplicative carcinogenic effect would be produced by the action of different carcinogens in a mixture on different stages of the carcinogenic process. An additive effect would be produced by the effect of different carcinogens on the same stage. A mathematical argument for these hypotheses is presented here.

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Year:  1986        PMID： 3615986     DOI： 10.1111/j.1539-6924.1986.tb00204.x

Source DB:  PubMed          Journal:  Risk Anal        ISSN： 0272-4332            Impact factor:   4.000


  3 in total

1.  Lung tumorigenic interactions in strain A/J mice of five environmental polycyclic aromatic hydrocarbons.

Authors:  S Nesnow; M J Mass; J A Ross; A J Galati; G R Lambert; C Gennings; W H Carter; G D Stoner
Journal:  Environ Health Perspect       Date:  1998-12       Impact factor: 9.031

Review 2.  Recent developments in the multistage modeling of cohort data for carcinogenic risk assessment.

Authors:  S Mazumdar; C K Redmond; J P Costantino; R N Patwardhan; S Y Zhou
Journal:  Environ Health Perspect       Date:  1991-01       Impact factor: 9.031

3.  Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons.

Authors:  Karina Lindner; Michael Ströbele; Sandra Schlick; Sina Webering; André Jenckel; Johannes Kopf; Olga Danov; Katherina Sewald; Christian Buj; Otto Creutzenberg; Thomas Tillmann; Gerhard Pohlmann; Heinrich Ernst; Christina Ziemann; Gereon Hüttmann; Holger Heine; Henning Bockhorn; Tanja Hansen; Peter König; Heinz Fehrenbach
Journal:  Part Fibre Toxicol       Date:  2017-03-21       Impact factor: 9.400
  3 in total

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