Mayur Parkhi1, Suvradeep Mitra1, Debajyoti Chatterjee1, Nitin J Peters2. 1. Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. 2. Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Abstract
Background: Teratoid hepatoblastoma is an uncommon but well-recognized variant of mixed hepatoblastoma. Case report: A one-year female child presented with palpable and progressively increasing right abdominal mass for 3 months. The contrast-enhancing computed tomography (CECT) abdomen revealed a large heterogeneous hepatic mass measuring 12 × 6.6 × 6 cm. Histopathological examination of the resected specimen showed a mixed hepatoblastoma (epithelial and mesenchymal) with teratoid features and multi-lineage differentiation (all three germ cell layers). A focus showed embryonal rhabdomyosarcomatous element. Conclusion: Teratoid hepatoblastoma can show a wide range of heterologous differentiation that may pose a significant diagnostic dilemma. Such a broad spectrum has not been described in the literature previously. An appropriate immunohistochemical panel may be needed to identify and delineate the various heterologous differentiation to clinch the correct diagnosis. Secondary somatic malignancy such as rhabdomyosarcoma can develop in a teratomatous element.
Background: Teratoid hepatoblastoma is an uncommon but well-recognized variant of mixed hepatoblastoma. Case report: A one-year female child presented with palpable and progressively increasing right abdominal mass for 3 months. The contrast-enhancing computed tomography (CECT) abdomen revealed a large heterogeneous hepatic mass measuring 12 × 6.6 × 6 cm. Histopathological examination of the resected specimen showed a mixed hepatoblastoma (epithelial and mesenchymal) with teratoid features and multi-lineage differentiation (all three germ cell layers). A focus showed embryonal rhabdomyosarcomatous element. Conclusion: Teratoid hepatoblastoma can show a wide range of heterologous differentiation that may pose a significant diagnostic dilemma. Such a broad spectrum has not been described in the literature previously. An appropriate immunohistochemical panel may be needed to identify and delineate the various heterologous differentiation to clinch the correct diagnosis. Secondary somatic malignancy such as rhabdomyosarcoma can develop in a teratomatous element.
Authors: Rebecka L Meyers; Greg Tiao; Jean de Ville de Goyet; Riccardo Superina; Daniel C Aronson Journal: Curr Opin Pediatr Date: 2014-02 Impact factor: 2.856
Authors: Alexander Moll; Alexander Krenauer; Uta Bierbach; Holger Till; Wolfgang Hirsch; Ivo Leuschner; Nicole Schmitz; Christian Wittekind; Thomas Aigner Journal: Diagn Pathol Date: 2009-11-12 Impact factor: 2.644