Literature DB >> 36157102

Time isn't kind to female T-cells.

Cassandra J McGill1,2, Bérénice A Benayoun1,3,4,5,6.   

Abstract

While investigating sex-differences in T-cell aging, Mkhikian et al., identified a role for excessive IL-7 signaling and N-glycan branching in age-related mouse and human female T-cell dysfunction. These findings point to the increasingly-recognized importance of the impact of biological sex on immune aging and delineate new targetable pathways in age-related immune dysfunction.

Entities:  

Year:  2022        PMID： 36157102      PMCID： PMC9496640          DOI： 10.1038/s43587-022-00185-0

Source DB:  PubMed          Journal:  Nat Aging        ISSN： 2662-8465


  15 in total

1.  Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.

Authors:  Ineke den Braber; Tendai Mugwagwa; Nienke Vrisekoop; Liset Westera; Ramona Mögling; Anne Bregje de Boer; Neeltje Willems; Elise H R Schrijver; Gerrit Spierenburg; Koos Gaiser; Erik Mul; Sigrid A Otto; An F C Ruiter; Mariette T Ackermans; Frank Miedema; José A M Borghans; Rob J de Boer; Kiki Tesselaar
Journal:  Immunity       Date:  2012-02-24       Impact factor: 31.745

2.  N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells.

Authors:  Rodney Morgan; Guoyan Gao; Judy Pawling; James W Dennis; Michael Demetriou; Baiyong Li
Journal:  J Immunol       Date:  2004-12-15       Impact factor: 5.422

3.  Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching.

Authors:  Haik Mkhikian; Ken L Hayama; Khachik Khachikyan; Carey Li; Raymond W Zhou; Judy Pawling; Suzi Klaus; Phuong Q N Tran; Kim M Ly; Andrew D Gong; Hayk Saryan; Jasper L Hai; David Grigoryan; Philip L Lee; Barbara L Newton; Manuela Raffatellu; James W Dennis; Michael Demetriou
Journal:  Nat Aging       Date:  2022-03-18

4.  Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies.

Authors:  P E Goss; C L Reid; D Bailey; J W Dennis
Journal:  Clin Cancer Res       Date:  1997-07       Impact factor: 12.531

5.  Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.

Authors:  Ken S Lau; Emily A Partridge; Ani Grigorian; Cristina I Silvescu; Vernon N Reinhold; Michael Demetriou; James W Dennis
Journal:  Cell       Date:  2007-04-06       Impact factor: 41.582

6.  Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity.

Authors:  L Renee Ruhaak; Hae-Won Uh; Marian Beekman; Carolien A M Koeleman; Cornelis H Hokke; Rudi G J Westendorp; Manfred Wuhrer; Jeanine J Houwing-Duistermaat; P Eline Slagboom; André M Deelder
Journal:  PLoS One       Date:  2010-09-07       Impact factor: 3.240

7.  Immunosenescence Study of T Cells: A Systematic Review.

Authors:  Ivon Johanna Rodriguez; Nicolás Lalinde Ruiz; Manuela Llano León; Laura Martínez Enríquez; María Del Pilar Montilla Velásquez; Juan Pablo Ortiz Aguirre; Oscar Mauricio Rodríguez Bohórquez; Esteban Alejandro Velandia Vargas; Edgar Debray Hernández; Carlos Alberto Parra López
Journal:  Front Immunol       Date:  2021-01-15       Impact factor: 7.561

8.  Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.

Authors:  Eric J Yager; Mushtaq Ahmed; Kathleen Lanzer; Troy D Randall; David L Woodland; Marcia A Blackman
Journal:  J Exp Med       Date:  2008-03-10       Impact factor: 14.307

9.  Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis.

Authors:  Haik Mkhikian; Christie-Lynn Mortales; Raymond W Zhou; Khachik Khachikyan; Gang Wu; Stuart M Haslam; Patil Kavarian; Anne Dell; Michael Demetriou
Journal:  Elife       Date:  2016-06-08       Impact factor: 8.140

10.  ImmGen report: sexual dimorphism in the immune system transcriptome.

Authors:  Shani Talia Gal-Oz; Barbara Maier; Hideyuki Yoshida; Kumba Seddu; Nitzan Elbaz; Charles Czysz; Or Zuk; Barbara E Stranger; Hadas Ner-Gaon; Tal Shay
Journal:  Nat Commun       Date:  2019-09-20       Impact factor: 14.919
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