Shengsheng Wei1,2, Jing Li2, Yong Li2, Yaohua Zhang2, Yan Cai2, Jing Du2, Jianguo Liu2, Yan Wang3,4. 1. Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China. 2. Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China. 3. Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China. wangyan7143@vip.sina.com. 4. Tianjin Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin Medical University, No. 4 Gansu Road, He-ping District, Tianjin, 300020, China. wangyan7143@vip.sina.com.
Abstract
PURPOSE: To investigate corneal densitometry and correlations with corneal morphological parameters in patients with bilateral keratoconus (KC) with unilateral Vogt's striae. METHODS: This prospective contralateral study enrolled 112 patients (224 eyes) with evident KC characteristics (corneal topography with asymmetric bow-tie pattern, inferior steepening), and at least one KC sign (conical protrusion of the cornea at the apex, corneal stromal thinning, Fleischer ring, Vogt's striae) on slit-lamp examination. Corneal densitometry and morphological parameters were measured using Pentacam HR. RESULTS: The mean age was 23.93 ± 6.81 years. Fifty-two (23.22%), 111 (49.55%), and 61 (27.23%) eyes were in mild, moderate, and severe groups, respectively. Corneal densitometry values of the anterior 0-2 mm and 2-6 mm, intermediate 0-2 mm and 2-6 mm, posterior 2-6 mm, and total cornea 2-6 mm were significantly higher in eyes with Vogt's striae (P < 0.05), whereas those of the anterior 6-10 mm, posterior 0-2 mm, and total cornea 6-10 mm were significantly lower in eyes with Vogt's striae (P < 0.05). Anterior 0-2 mm and total cornea 2-6 mm corneal densitometry values were positively correlated with anterior K1 (A-K1), K2 (A-K2), Km (A-Km), Kmax (A-Kmax), anterior corneal elevation, and posterior corneal elevation (P < 0.05), and negatively correlated with central corneal thickness and thinnest corneal thickness in eyes with Vogt's striae (P < 0.05). A-K2, A-Km, and A-Kmax were significantly correlated with the densitometry values of the anterior 0-2 mm and intermediate 0-2 mm in eyes without Vogt's striae (P < 0.05). CONCLUSION: Vogt's striae mainly occur on the anterior and intermediate layers during KC progression.
PURPOSE: To investigate corneal densitometry and correlations with corneal morphological parameters in patients with bilateral keratoconus (KC) with unilateral Vogt's striae. METHODS: This prospective contralateral study enrolled 112 patients (224 eyes) with evident KC characteristics (corneal topography with asymmetric bow-tie pattern, inferior steepening), and at least one KC sign (conical protrusion of the cornea at the apex, corneal stromal thinning, Fleischer ring, Vogt's striae) on slit-lamp examination. Corneal densitometry and morphological parameters were measured using Pentacam HR. RESULTS: The mean age was 23.93 ± 6.81 years. Fifty-two (23.22%), 111 (49.55%), and 61 (27.23%) eyes were in mild, moderate, and severe groups, respectively. Corneal densitometry values of the anterior 0-2 mm and 2-6 mm, intermediate 0-2 mm and 2-6 mm, posterior 2-6 mm, and total cornea 2-6 mm were significantly higher in eyes with Vogt's striae (P < 0.05), whereas those of the anterior 6-10 mm, posterior 0-2 mm, and total cornea 6-10 mm were significantly lower in eyes with Vogt's striae (P < 0.05). Anterior 0-2 mm and total cornea 2-6 mm corneal densitometry values were positively correlated with anterior K1 (A-K1), K2 (A-K2), Km (A-Km), Kmax (A-Kmax), anterior corneal elevation, and posterior corneal elevation (P < 0.05), and negatively correlated with central corneal thickness and thinnest corneal thickness in eyes with Vogt's striae (P < 0.05). A-K2, A-Km, and A-Kmax were significantly correlated with the densitometry values of the anterior 0-2 mm and intermediate 0-2 mm in eyes without Vogt's striae (P < 0.05). CONCLUSION: Vogt's striae mainly occur on the anterior and intermediate layers during KC progression.