Chun-Yu Lin1, Xin Song2, Kimberly Seaman2, Lidan You3,4. 1. Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. 2. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada. 3. Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. youlidan@mie.utoronto.ca. 4. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada. youlidan@mie.utoronto.ca.
Abstract
PURPOSE OF REVIEW: Osteocytes are the most abundant cell type in bone. These unique cells act primarily as mechanosensors and play crucial roles in the functional adaptation of bone tissue. This review aims to summarize the recent microfluidic studies on mechanically stimulated osteocytes in regulating other cell types. RECENT FINDINGS: Microfluidics is a powerful technology that has been widely employed in recent years. With the advantages of microfluidic platforms, researchers can mimic multicellular environments and integrate dynamic systems to study osteocyte regulation under mechanical stimulation. Microfluidic platforms have been developed to investigate mechanically stimulated osteocytes in the direct regulation of multiple cell types, including osteoclasts, osteoblasts, and cancer cells, and in the indirect regulation of cancer cells via endothelial cells. Overall, these microfluidic studies foster the development of treatment approaches targeting osteocytes under mechanical stimulation.
PURPOSE OF REVIEW: Osteocytes are the most abundant cell type in bone. These unique cells act primarily as mechanosensors and play crucial roles in the functional adaptation of bone tissue. This review aims to summarize the recent microfluidic studies on mechanically stimulated osteocytes in regulating other cell types. RECENT FINDINGS: Microfluidics is a powerful technology that has been widely employed in recent years. With the advantages of microfluidic platforms, researchers can mimic multicellular environments and integrate dynamic systems to study osteocyte regulation under mechanical stimulation. Microfluidic platforms have been developed to investigate mechanically stimulated osteocytes in the direct regulation of multiple cell types, including osteoclasts, osteoblasts, and cancer cells, and in the indirect regulation of cancer cells via endothelial cells. Overall, these microfluidic studies foster the development of treatment approaches targeting osteocytes under mechanical stimulation.
Authors: Yilin Wang; Laoise M McNamara; Mitchell B Schaffler; Sheldon Weinbaum Journal: Proc Natl Acad Sci U S A Date: 2007-09-25 Impact factor: 11.205
Authors: Rishikesh N Kulkarni; Astrid D Bakker; Vincent Everts; Jenneke Klein-Nulend Journal: Biochem Biophys Res Commun Date: 2012-02-27 Impact factor: 3.575
Authors: Wing-Yee Cheung; Chao Liu; Rachel M L Tonelli-Zasarsky; Craig A Simmons; Lidan You Journal: J Orthop Res Date: 2010-10-26 Impact factor: 3.494
Authors: Janak L Pathak; N Bravenboer; Frank P Luyten; Patrick Verschueren; Willem F Lems; Jenneke Klein-Nulend; Astrid D Bakker Journal: Calcif Tissue Int Date: 2015-05-13 Impact factor: 4.333