Literature DB >> 36149442

[Paraneoplastic hyperleukocytosis in lung cancer].

Josef Heusinger1, Paul Czech2, Heidi Hengstler3, Frank Schaumann3, Anja Rückert3, Frank Schmid4, Jörg Kalla5, Uta Diergardt5, Hinrich Bremer6, Paul La Rosée3.   

Abstract

Paraneoplastic leukocytosis in solid tumors is associated with poor prognosis. While mild leukocytosis is common, paraneoplastic hyperleukocytosis is extremely rare. The case of a 73-year-old male diagnosed with an adenocarcinoma of the lung and a peak white blood cell count of 178,000/µl is reported. The patient succumbed to the disease after two cycles of immunochemotherapy only 2 months after first hospital admission. Specific treatment options are still under investigation and have not been reported in clinical use.
© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Entities:  

Keywords:  Carcinoma; Carcinoma, non-small-cell lung; Granulocyte colony-stimulating factor; Leukemoid reaction; Paraneoplastic syndromes

Year:  2022        PMID： 36149442     DOI： 10.1007/s00108-022-01407-8

Source DB:  PubMed          Journal:  Inn Med (Heidelb)        ISSN： 2731-7080


  6 in total

1.  Leukemoid reaction in lung cancer patients.

Authors:  Guy Shalom; Netta Sion-Vardy; Julia Dudnik; Samuel Ariad
Journal:  Isr Med Assoc J       Date:  2010-04       Impact factor: 0.892

2.  Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.

Authors:  Hideshi Nakata; Yoshiki Uemura; Makoto Kobayashi; Ryoji Harada; Hirokuni Taguchi
Journal:  Cancer Sci       Date:  2003-02       Impact factor: 6.716

3.  Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment.

Authors:  Vernon T Phan; Xiumin Wu; Jason H Cheng; Rebecca X Sheng; Alicia S Chung; Guanglei Zhuang; Christopher Tran; Qinghua Song; Marcin Kowanetz; Amy Sambrone; Martha Tan; Y Gloria Meng; Erica L Jackson; Franklin V Peale; Melissa R Junttila; Napoleone Ferrara
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-25       Impact factor: 11.205

Review 4.  Hyperleukocytosis, an unusual paraneoplastic manifestation of lung cancer: Case report and review of literature.

Authors:  Aparna Sreevatsa; Suresh M C Babu; Govind K Babu; T M Suresh
Journal:  J Cancer Res Ther       Date:  2015 Jul-Sep       Impact factor: 1.805

5.  Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients: a retrospective, single-institution study.

Authors:  John M Granger; Dimitrios P Kontoyiannis
Journal:  Cancer       Date:  2009-09-01       Impact factor: 6.860

6.  Leukemoid reaction in a patient with adenocarcinoma of the lung: a case report.

Authors:  Hendrik Riesenberg; Frauke Müller; Martin Görner
Journal:  J Med Case Rep       Date:  2012-07-19
  6 in total

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