Literature DB >> 3614763

Identification of N-carboxyethyl gamma-aminobutyric acid in bovine brain and human cerebrospinal fluid.

F Fussi, F Savoldi, M Curti.   

Abstract

The di-carboxylated derivative of spermidine, N-carboxyethyl gamma-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.

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Year:  1987        PMID： 3614763     DOI： 10.1016/0304-3940(87)90518-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  2 in total

Review 1.  Clinical relevance of measuring GABA concentrations in cerebrospinal fluid.

Authors:  P J Schechter; A Sjoerdsma
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

Review 2.  Review: Normal and abnormal central nervous system GABA metabolism in childhood.

Authors:  J Jaeken; P Casaer; K D Haegele; P J Schechter
Journal:  J Inherit Metab Dis       Date:  1990       Impact factor: 4.982
  2 in total

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