Literature DB >> 3614666

Smooth pursuit during dose-related on-off fluctuations in Parkinson's disease.

J A Sharpe, W A Fletcher, A E Lang, D H Zackon.   

Abstract

Smooth pursuit was studied during predictable L-dopa dose-related "off" periods of morning akinesia and wearing off and during "on" periods in eight patients with idiopathic Parkinson's disease. Smooth pursuit gain was significantly reduced in patients during both on and off phases. Despite marked fluctuations between parkinsonism and periods of near normal skeletal motion, there were no changes in smooth pursuit gain. We conclude that unvarying paresis of smooth pursuit in Parkinson's disease signifies involvement of neural circuits that are distinct from the dopaminergic mechanisms that mediate the on-off phenomenon of somatic motor control.

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Year:  1987        PMID： 3614666     DOI： 10.1212/wnl.37.8.1389

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

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Authors:  Victoria S Pelak
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Review 5.  Pharmacological treatment effects on eye movement control.

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6.  Cognitive functions and stereopsis in patients with Parkinson's disease and Alzheimer's disease using 3-dimensional television: a case controlled trial.

Authors:  Chan-Nyoung Lee; Deokwon Ko; Young-Woo Suh; Kun-Woo Park
Journal:  PLoS One       Date:  2015-03-30       Impact factor: 3.240

7.  Impaired smooth-pursuit in Parkinson's disease: normal cue-information memory, but dysfunction of extra-retinal mechanisms for pursuit preparation and execution.

Authors:  Kikuro Fukushima; Norie Ito; Graham R Barnes; Sachiyo Onishi; Nobuyoshi Kobayashi; Hidetoshi Takei; Peter M Olley; Susumu Chiba; Kiyoharu Inoue; Tateo Warabi
Journal:  Physiol Rep       Date:  2015-03

8.  Abnormal Eye Movements in Parkinsonism and Movement Disorders.

Authors:  Ileok Jung; Ji-Soo Kim
Journal:  J Mov Disord       Date:  2019-01-30

9.  Freezing of saccades in dopa-responsive parkinsonian syndrome.

Authors:  Techawit Likitgorn; Yan Yan; Yaping Joyce Liao
Journal:  Am J Ophthalmol Case Rep       Date:  2021-05-23

10.  Excessive Sensitivity to Uncertain Visual Input in L-DOPA-Induced Dyskinesias in Parkinson's Disease: Further Implications for Cerebellar Involvement.

Authors:  James K R Stevenson; Chonho Lee; Bu-Sung Lee; Pouria Talebifard; Edna Ty; Kristina Aseeva; Meeko M K Oishi; Martin J McKeown
Journal:  Front Neurol       Date:  2014-02-04       Impact factor: 4.003
  10 in total

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