Literature DB >> 3613466

Fosfomycin protects against tubulotoxicity induced by cis-diaminedichloroplatin and cyclosporin A in the rat.

K Sack, E Schulz, R Marre, B Kreft.   

Abstract

The nephroprotective effect of fosfomycin against tubulotoxicity induced by cis-diaminedichloroplatin (DDP) and cyclosporin A (Cs) was studied in the rat. The parameter of nephrotoxicity was urinary tubular cell excretion. The experiments revealed that fosfomycin, given either concomitantly or in advance was able to reduce the nephrotoxic effect of DDP and Cs significantly. We conclude from these studies that fosfomycin is a broad-spectrum nephroprotective agent.

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Year:  1987        PMID： 3613466     DOI： 10.1007/bf01721040

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  6 in total

1.  Experimental investigations of cefuroxime in renal tolerance and therapeutic efficacy in pyelonephritis.

Authors:  K Sack; H Freiesleben; E Schulz; R Marre; W Henkel
Journal:  Proc R Soc Med       Date:  1977

2.  An effect of fosfomycin on the pharmacokinetics of amikacin.

Authors:  K Fujita
Journal:  J Antibiot (Tokyo)       Date:  1984-04       Impact factor: 2.649

3.  Influence of fosfomycin and tobramycin on vancomycin-induced nephrotoxicity.

Authors:  R Marre; E Schulz; D Hedtke; K Sack
Journal:  Infection       Date:  1985 Jul-Aug       Impact factor: 3.553

4.  Protective effect of fosfomycin on the experimental nephrotoxicity induced by dibekacin.

Authors:  S Inouye; T Niizato; U Takeda; T Koeda
Journal:  J Pharmacobiodyn       Date:  1982-09

5.  [Can fosfomycin reduce the nephrotoxicity of aminoglycosides?].

Authors:  J P Morin; B Olier; G Viotte; J P Fillastre
Journal:  Pathol Biol (Paris)       Date:  1984-05

6.  [Preventive effect of fosfomycin on the renal toxicity of cisplatin].

Authors:  M Kurebe; T Niizato; M Sanda; H Sasaki; H Hayasaka
Journal:  Jpn J Antibiot       Date:  1985-01
  6 in total
  4 in total

1.  Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice.

Authors:  T Matsumoto; K Tateda; S Miyazaki; N Furuya; A Ohno; Y Ishii; Y Hirakata; K Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

2.  The microbiological efficacy of the combination of fosfomycin and vancomycin against clinically relevant staphylococci.

Authors:  S Gatermann; E Schulz; R Marre
Journal:  Infection       Date:  1989 Jan-Feb       Impact factor: 3.553

3.  Effects of fosfomycin, mesna, and sodium thiosulfate on the toxicity and antitumor activity of cisplatin.

Authors:  T Wagner; B Kreft; G Bohlmann; G Schwieder
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

Review 4.  Fosfomycin: Uses and potentialities in veterinary medicine.

Authors:  D S Pérez; M O Tapia; A L Soraci
Journal:  Open Vet J       Date:  2014-03-16
  4 in total

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