Literature DB >> 3612689

gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity.

L M Nguyen, E Niesor, C L Bentzen.   

Abstract

New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of numerous compounds has permitted the determination of the structural variations leading to optimal plasma lipid altering activity, indicating antiatherosclerotic potential. Among the compounds observed to be the most active, dimethyl alpha-(dimethoxyphosphinyl)-p-chlorobenzyl phosphate (20, SR-202, mifobate) was selected for further pharmacological and subsequent clinical development.

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Year:  1987        PMID： 3612689     DOI： 10.1021/jm00391a027

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  Synthesis and reactivity of alkyl-1,1,1-trisphosphonate esters.

Authors:  Jacqueline P Smits; David F Wiemer
Journal:  J Org Chem       Date:  2011-10-04       Impact factor: 4.354

2.  Flavin Metallaphotoredox Catalysis: Synergistic Synthesis in Water.

Authors:  Maheshwerreddy Chilamari; Jacob R Immel; Pei-Hsuan Chen; Bayan M Alghafli; Steven Bloom
Journal:  ACS Catal       Date:  2022-03-22       Impact factor: 13.700

3.  Monomers for adhesive polymers, 18. Synthesis, photopolymerization and adhesive properties of polymerizable α-phosphonooxy phosphonic acids.

Authors:  Yohann Catel; Cédéric Dellsperger; Norbert Moszner
Journal:  Des Monomers Polym       Date:  2016-09-29       Impact factor: 2.650

Review 4.  Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs.

Authors:  Joice Castelo Branco Santos; Jonathas Alves de Melo; Sweta Maheshwari; Wendy Marina Toscano Queiroz de Medeiros; Johny Wysllas de Freitas Oliveira; Cláudia Jassica Moreno; L Mario Amzel; Sandra B Gabelli; Marcelo Sousa Silva
Journal:  Molecules       Date:  2020-06-03       Impact factor: 4.411

Review 5.  H-Phosphonate Chemistry in the Synthesis of Electrically Neutral and Charged Antiviral and Anticancer Pronucleotides.

Authors:  Adam Kraszewski; Michal Sobkowski; Jacek Stawinski
Journal:  Front Chem       Date:  2020-11-13       Impact factor: 5.221
  5 in total

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