Literature DB >> 36125710

Induction of Bile Canaliculi-Forming Hepatocytes from Human Pluripotent Stem Cells.

Lavinija Matakovic1, Arend W Overeem1,2, Karin Klappe1, Sven C D van IJzendoorn3.   

Abstract

Cell polarity and formation of bile canaliculi can be achieved in hepatocytes which are generated from patient-derived induced pluripotent stem cells. This allows for the study of endogenous mutant proteins, patient-specific pathogenesis, and drug responses for diseases where hepatocyte polarity and bile canaliculi play a key role. Here, we describe a step-by-step protocol for the generation of bile canaliculi-forming hepatocytes from induced pluripotent stem cells and their evaluation.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Bile canaliculus; Hepatocyte; Hepatocyte polarity; Induced pluripotent stem cell; Inherited liver disease

Mesh：

Substances：

Year:  2022        PMID： 36125710     DOI： 10.1007/978-1-0716-2557-6_4

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  30 in total

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Authors:  A B Shah; I Chernov; H T Zhang; B M Ross; K Das; S Lutsenko; E Parano; L Pavone; O Evgrafov; I A Ivanova-Smolenskaya; G Annerén; K Westermark; F H Urrutia; G K Penchaszadeh; I Sternlieb; I H Scheinberg; T C Gilliam; K Petrukhin
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

Review 2.  Hepatocyte polarity.

Authors:  Aleksandr Treyer; Anne Müsch
Journal:  Compr Physiol       Date:  2013-01       Impact factor: 9.090

Review 3.  Progressive Familial Intrahepatic Cholestasis.

Authors:  Laura N Bull; Richard J Thompson
Journal:  Clin Liver Dis       Date:  2018-08-03       Impact factor: 6.126

4.  Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells.

Authors:  Karim Si-Tayeb; Fallon K Noto; Masato Nagaoka; Jixuan Li; Michele A Battle; Christine Duris; Paula E North; Stephen Dalton; Stephen A Duncan
Journal:  Hepatology       Date:  2010-01       Impact factor: 17.425

Review 5.  Progressive familial intrahepatic cholestasis.

Authors:  Emmanuel Jacquemin
Journal:  Clin Res Hepatol Gastroenterol       Date:  2012-09       Impact factor: 2.947

6.  Functional rescue of an ABCB11 mutant by ivacaftor: A new targeted pharmacotherapy approach in bile salt export pump deficiency.

Authors:  Elodie Mareux; Martine Lapalus; Rachida Amzal; Marion Almes; Tounsia Aït-Slimane; Jean-Louis Delaunay; Pauline Adnot; Mauricette Collado-Hilly; Anne Davit-Spraul; Thomas Falguières; Isabelle Callebaut; Emmanuel Gonzales; Emmanuel Jacquemin
Journal:  Liver Int       Date:  2020-06-08       Impact factor: 5.828

7.  A novel cellular phenotype for familial hypercholesterolemia due to a defect in polarized targeting of LDL receptor.

Authors:  U M Koivisto; A L Hubbard; I Mellman
Journal:  Cell       Date:  2001-06-01       Impact factor: 41.582

8.  MEDNIK syndrome: a novel defect of copper metabolism treatable by zinc acetate therapy.

Authors:  Diego Martinelli; Lorena Travaglini; Christian A Drouin; Irene Ceballos-Picot; Teresa Rizza; Enrico Bertini; Rosalba Carrozzo; Stefania Petrini; Pascale de Lonlay; Maya El Hachem; Laurence Hubert; Alexandre Montpetit; Giuliano Torre; Carlo Dionisi-Vici
Journal:  Brain       Date:  2013-02-18       Impact factor: 13.501

Review 9.  Structural and functional hepatocyte polarity and liver disease.

Authors:  Paul Gissen; Irwin M Arias
Journal:  J Hepatol       Date:  2015-06-24       Impact factor: 25.083

Review 10.  Current and future therapies for inherited cholestatic liver diseases.

Authors:  Wendy L van der Woerd; Roderick Hj Houwen; Stan Fj van de Graaf
Journal:  World J Gastroenterol       Date:  2017-02-07       Impact factor: 5.742
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