| Literature DB >> 3612568 |
A K Al-Modhefer, J C Atherton, H O Garland, H J Singh, J Walker.
Abstract
Single-nephron and whole-kidney function were studied in female rats with corticomedullary nephrocalcinosis, and in animals where the lesion had been prevented either by a dietary magnesium supplement or by using a diet with a calcium:phosphorus ratio in excess of 1. At the single-nephron level, rats with nephrocalcinosis had prolonged tubular fluid transit times. Proximal transit time was 19.42 +/- 1.98 (mean +/- S.E. of mean) vs. 11.58 +/- 0.19 s for controls; distal transit time was 62.64 +/- 9.16 vs. 31.50 +/- 1.03 s for controls. Although single-nephron function is altered in nephrocalcinosis, data obtained from rats in metabolism cages indicate that whole-kidney function is largely unaffected by the lesion.Entities:
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Year: 1986 PMID： 3612568 PMCID： PMC1182945 DOI： 10.1113/jphysiol.1986.sp016293
Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182