Hussein M Abdallah1, Arka N Mallela2,3, Zhishuo Wei1, Hussam Abou-Al-Shaar4, Ajay Niranjan4, L Dade Lunsford4. 1. University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 2. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. mallelaan@upmc.edu. 3. Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, USA. mallelaan@upmc.edu. 4. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract
PURPOSE: Meningiomas arising from the confluence of the falx and tentorium (CFT) are a rare and challenging subset of meningiomas. Gamma Knife radiosurgery (GKRS) is well-established as a safe and effective management strategy for intracranial meningiomas, but its role in treating CFT meningiomas is not well-described. This paper reports the largest series focused exclusively on the outcomes of GKRS for CFT meningiomas. METHODS: We retrospectively identified 20 CFT meningiomas out of 2031 meningioma patients who underwent GKRS at our institution between 1987 and 2021. Tumor control, overall survival (OS), and complications were recorded and analyzed. The median tumor margin dose was 13 Gy at the 50% isodose line. The median tumor volume treated was 4.4 cc (IQR 3.5-7.7). The median patient age was 58 years (range 33-83), the median MRI surveillance duration was 59 months (IQR 34-92), and the median overall follow-up duration was 92 months (IQR 42-201). RESULTS: The local tumor control rate (PFS) at 5 and 10-years were 100% (N=10) and 83% (N=4), respectively. Eight patients had stable tumor volumes and 11 patients had regression. One patient with a twice-operated tumor had delayed progression at 7.5 years and was retreated with GKRS. No patient had adverse radiation effects during the period of MRI surveillance. The 5 and 10-year OS were 100% (N=13) and 100% (N=7), respectively. CONCLUSIONS: GKRS is a valuable therapeutic strategy for patients with newly diagnosed CFT meningiomas or progressive residual tumors after surgical resection.
PURPOSE: Meningiomas arising from the confluence of the falx and tentorium (CFT) are a rare and challenging subset of meningiomas. Gamma Knife radiosurgery (GKRS) is well-established as a safe and effective management strategy for intracranial meningiomas, but its role in treating CFT meningiomas is not well-described. This paper reports the largest series focused exclusively on the outcomes of GKRS for CFT meningiomas. METHODS: We retrospectively identified 20 CFT meningiomas out of 2031 meningioma patients who underwent GKRS at our institution between 1987 and 2021. Tumor control, overall survival (OS), and complications were recorded and analyzed. The median tumor margin dose was 13 Gy at the 50% isodose line. The median tumor volume treated was 4.4 cc (IQR 3.5-7.7). The median patient age was 58 years (range 33-83), the median MRI surveillance duration was 59 months (IQR 34-92), and the median overall follow-up duration was 92 months (IQR 42-201). RESULTS: The local tumor control rate (PFS) at 5 and 10-years were 100% (N=10) and 83% (N=4), respectively. Eight patients had stable tumor volumes and 11 patients had regression. One patient with a twice-operated tumor had delayed progression at 7.5 years and was retreated with GKRS. No patient had adverse radiation effects during the period of MRI surveillance. The 5 and 10-year OS were 100% (N=13) and 100% (N=7), respectively. CONCLUSIONS: GKRS is a valuable therapeutic strategy for patients with newly diagnosed CFT meningiomas or progressive residual tumors after surgical resection.
Authors: Clinton J Baird; James E Conway; Daniel M Sciubba; Daniel M Prevedello; Alfredo Quiñones-Hinojosa; Amin B Kassam Journal: Neurosurgery Date: 2009-12 Impact factor: 4.654
Authors: Vijay Agarwal; Brandon A McCutcheon; Joshua D Hughes; Matthew L Carlson; Amy E Glasgow; Elizabeth B Habermann; Quoc-Bao Nguyen; Michael J Link; Jamie J Van Gompel Journal: World Neurosurg Date: 2017-06-27 Impact factor: 2.104
Authors: John C Flickinger; Douglas Kondziolka; Ajay Niranjan; Ann Maitz; George Voynov; L Dade Lunsford Journal: Int J Radiat Oncol Biol Phys Date: 2004-09-01 Impact factor: 7.038
Authors: Jason Sheehan; Stylianos Pikis; Abdurrahman I Islim; Ching-Jen Chen; Adomas Bunevicius; Selcuk Peker; Yavuz Samanci; Ahmed M Nabeel; Wael A Reda; Sameh R Tawadros; Amr M N El-Shehaby; Khaled Abdelkarim; Reem M Emad; Violaine Delabar; David Mathieu; Cheng-Chia Lee; Huai-Che Yang; Roman Liscak; Jaromir Hanuska; Roberto Martinez Alvarez; Dev Patel; Douglas Kondziolka; Nuria Martinez Moreno; Manjul Tripathi; Herwin Speckter; Camilo Albert; Greg N Bowden; Ronald J Benveniste; Lawrence Dade Lunsford; Michael D Jenkinson Journal: Neuro Oncol Date: 2022-01-05 Impact factor: 13.029
Authors: Chang Ki Hong; Je Beom Hong; Hunho Park; Ju Hyung Moon; Jong Hee Chang; Kyu Sung Lee; Seoung Woo Park Journal: Yonsei Med J Date: 2016-07 Impact factor: 2.759