Literature DB >> 36121422

Balancing cell polarity PARts through dephosphorylation.

André Barros-Carvalho1,2, Eurico Morais-de-Sá1,2.   

Abstract

How cells spatially organize their plasma membrane, cytoskeleton, and cytoplasm remains a central question for cell biologists. In this issue of JCB, Calvi et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202201048) identify PP1 phosphatases as key regulators of C. elegans anterior-posterior polarity, by counterbalancing aPKC-mediated phosphorylation of PAR-2.
© 2022 Barros-Carvalho and Morais-de-Sa.

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Year:  2022        PMID： 36121422      PMCID： PMC9486083          DOI： 10.1083/jcb.202208008

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   8.077


  10 in total

1.  Stabilization of cell polarity by the C. elegans RING protein PAR-2.

Authors:  Yingsong Hao; Lynn Boyd; Geraldine Seydoux
Journal:  Dev Cell       Date:  2006-02       Impact factor: 12.270

2.  PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity.

Authors:  Sofia Moreira; Mariana Osswald; Guilherme Ventura; Margarida Gonçalves; Claudio E Sunkel; Eurico Morais-de-Sá
Journal:  Cell Rep       Date:  2019-01-08       Impact factor: 9.423

3.  A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.

Authors:  Daniel J Dickinson; Francoise Schwager; Lionel Pintard; Monica Gotta; Bob Goldstein
Journal:  Dev Cell       Date:  2017-08-21       Impact factor: 12.270

Review 4.  The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity.

Authors:  Charles F Lang; Edwin Munro
Journal:  Development       Date:  2017-10-01       Impact factor: 6.868

5.  Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle.

Authors:  Erik E Griffin; David J Odde; Geraldine Seydoux
Journal:  Cell       Date:  2011-09-16       Impact factor: 41.582

6.  PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos.

Authors:  Ida Calvi; Françoise Schwager; Monica Gotta
Journal:  J Cell Biol       Date:  2022-09-09       Impact factor: 8.077

7.  Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.

Authors:  Andreas Traweger; Giselle Wiggin; Lorne Taylor; Stephen A Tate; Pavel Metalnikov; Tony Pawson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-18       Impact factor: 11.205

8.  A combined binary interaction and phenotypic map of C. elegans cell polarity proteins.

Authors:  Thijs Koorman; Diana Klompstra; Monique van der Voet; Irma Lemmens; João J Ramalho; Susan Nieuwenhuize; Sander van den Heuvel; Jan Tavernier; Jeremy Nance; Mike Boxem
Journal:  Nat Cell Biol       Date:  2016-01-18       Impact factor: 28.824

9.  Regulated Activation of the PAR Polarity Network Ensures a Timely and Specific Response to Spatial Cues.

Authors:  Jacob D Reich; Lars Hubatsch; Rukshala Illukkumbura; Florent Peglion; Tom Bland; Nisha Hirani; Nathan W Goehring
Journal:  Curr Biol       Date:  2019-05-30       Impact factor: 10.834

10.  Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy.

Authors:  Bruno Thomas Fievet; Josana Rodriguez; Sundar Naganathan; Christine Lee; Eva Zeiser; Takao Ishidate; Masaki Shirayama; Stephan Grill; Julie Ahringer
Journal:  Nat Cell Biol       Date:  2012-12-16       Impact factor: 28.824
  10 in total

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