Literature DB >> 36117545

Extracellular vesicles versus synthetic nanoparticles for drug delivery.

Kenneth W Witwer1,2, Joy Wolfram3,4,5.   

Abstract

Cell-released biological nanoparticles, including extracellular vesicles (EVs), are emerging drug carriers with high complexity. EV-based drug delivery has the potential to efficiently exploit intrinsic mechanisms for molecular transport in the body. Integrating the expanding knowledge of EV biology and manufacturing with clinical insights from synthetic nanoparticles is likely to substantially advance the field of drug delivery.

Entities:  

Year:  2021        PMID： 36117545      PMCID： PMC9481198          DOI： 10.1038/s41578-020-00277-6

Source DB:  PubMed          Journal:  Nat Rev Mater        ISSN： 2058-8437            Impact factor:   76.679


  10 in total

1.  Clinical Cancer Nanomedicine.

Authors:  Joy Wolfram; Mauro Ferrari
Journal:  Nano Today       Date:  2019-03-06       Impact factor: 20.722

Review 2.  Shedding light on the cell biology of extracellular vesicles.

Authors:  Guillaume van Niel; Gisela D'Angelo; Graça Raposo
Journal:  Nat Rev Mol Cell Biol       Date:  2018-01-17       Impact factor: 94.444

3.  Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone.

Authors:  Ryan Reshke; James A Taylor; Alexandre Savard; Huishan Guo; Luke H Rhym; Piotr S Kowalski; My Tran Trung; Charles Campbell; Wheaton Little; Daniel G Anderson; Derrick Gibbings
Journal:  Nat Biomed Eng       Date:  2020-01-14       Impact factor: 25.671

Review 4.  Extracellular vesicles as drug delivery systems: Why and how?

Authors:  Omnia M Elsharkasy; Joel Z Nordin; Daniel W Hagey; Olivier G de Jong; Raymond M Schiffelers; Samir El Andaloussi; Pieter Vader
Journal:  Adv Drug Deliv Rev       Date:  2020-04-16       Impact factor: 15.470

Review 5.  What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer.

Authors:  Kasper Bendix Johnsen; Johann Mar Gudbergsson; Thomas Lars Andresen; Jens Bæk Simonsen
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2018-12-07       Impact factor: 10.680

Review 6.  Lipoprotein-based drug delivery.

Authors:  Sara Busatto; Sierra A Walker; Whisper Grayson; Anthony Pham; Ming Tian; Nicole Nesto; Jacqueline Barklund; Joy Wolfram
Journal:  Adv Drug Deliv Rev       Date:  2020-08-11       Impact factor: 15.470

Review 7.  Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use.

Authors:  Mario Gimona; Karin Pachler; Sandra Laner-Plamberger; Katharina Schallmoser; Eva Rohde
Journal:  Int J Mol Sci       Date:  2017-06-03       Impact factor: 5.923

8.  Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications.

Authors:  Kenneth W Witwer; Bas W M Van Balkom; Stefania Bruno; Andre Choo; Massimo Dominici; Mario Gimona; Andrew F Hill; Dominique De Kleijn; Mickey Koh; Ruenn Chai Lai; S Alex Mitsialis; Luis A Ortiz; Eva Rohde; Takashi Asada; Wei Seong Toh; Daniel J Weiss; Lei Zheng; Bernd Giebel; Sai Kiang Lim
Journal:  J Extracell Vesicles       Date:  2019-04-29

9.  Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products.

Authors:  Maria Laggner; Alfred Gugerell; Christiane Bachmann; Helmut Hofbauer; Vera Vorstandlechner; Marcus Seibold; Ghazaleh Gouya Lechner; Anja Peterbauer; Sibylle Madlener; Svitlana Demyanets; Dirk Sorgenfrey; Tobias Ostler; Michael Erb; Michael Mildner; Hendrik Jan Ankersmit
Journal:  Stem Cell Res Ther       Date:  2020-01-03       Impact factor: 6.832

Review 10.  Extracellular vesicle-based drug delivery systems for cancer treatment.

Authors:  Sierra Walker; Sara Busatto; Anthony Pham; Ming Tian; Annie Suh; Kelsey Carson; Astrid Quintero; Maria Lafrence; Hanna Malik; Moises X Santana; Joy Wolfram
Journal:  Theranostics       Date:  2019-10-17       Impact factor: 11.556
  10 in total

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