Literature DB >> 3611263

Sensitive and selective determination of picogram amounts of ciprofloxacin and its metabolites in biological samples using high-performance liquid chromatography and photothermal post-column derivatization.

H Scholl, K Schmidt, B Weber.   

Abstract

An analytical method for the detection and quantification of ciprofloxacin and its known metabolites M1, M2, M3 and M4 in urine, serum/plasma, bile, faeces and tissue is described. For the liquid matrices the only sample preparation that is required is dilution. The assay consists of reversed-phase high-performance liquid chromatography and fluorescence detection. For the metabolites M2, M3 and M4 an additional post-column derivatization by successive thermolysis and photolysis is needed. A suitable simple post-column reactor has been constructed. Detection limits for all compounds are between 0.2 and 2.2 ng/ml (absolute detection limits 2-22 pg). Compared with fluorescence detection alone, the derivatization increases the selectivity of detection significantly. The linearity, precision and accuracy of the method were determined.

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Year:  1987        PMID： 3611263     DOI： 10.1016/0378-4347(87)80515-7

Source DB:  PubMed          Journal:  J Chromatogr


  9 in total

1.  Influence of intravenously administered ciprofloxacin on aerobic intestinal microflora and fecal drug levels when administered simultaneously with sucralfate.

Authors:  W A Krueger; G Ruckdeschel; K Unertl
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

2.  Ciprofloxacin absorption in different regions of the human gastrointestinal tract. Investigations with the hf-capsule.

Authors:  S Harder; U Fuhr; D Beermann; A H Staib
Journal:  Br J Clin Pharmacol       Date:  1990-07       Impact factor: 4.335

3.  Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients.

Authors:  H G Schaefer; H Stass; J Wedgwood; B Hampel; C Fischer; J Kuhlmann; U B Schaad
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191

4.  Penetration of ciprofloxacin into heart valves, myocardium, mediastinal fat, and sternal bone marrow in humans.

Authors:  P M Mertes; P Voiriot; C Dopff; H Scholl; M Clavey; J P Villemot; P Canton; J B Dureux
Journal:  Antimicrob Agents Chemother       Date:  1990-03       Impact factor: 5.191

5.  No interaction between ciprofloxacin and an oral contraceptive.

Authors:  P C Scholten; R M Droppert; M G Zwinkels; H L Moesker; J J Nauta; I M Hoepelman
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

Review 6.  Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  D M Campoli-Richards; J P Monk; A Price; P Benfield; P A Todd; A Ward
Journal:  Drugs       Date:  1988-04       Impact factor: 9.546

7.  Transintestinal elimination of ciprofloxacin in humans--concomitant assessment of its metabolites in serum, ileum and colon.

Authors:  B Viell; B Krause; K H Vestweber; S Schaaf; H Scholl
Journal:  Infection       Date:  1992 Nov-Dec       Impact factor: 3.553

8.  Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition.

Authors:  Simon N Muchohi; Nahashon Thuo; Japhet Karisa; Alex Muturi; Gilbert O Kokwaro; Kathryn Maitland
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2010-12-04       Impact factor: 3.205

9.  Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations.

Authors:  Sara da Silva Anacleto; Marcella Matos Cordeiro Borges; Hanna Leijoto de Oliveira; Andressa Reis Vicente; Eduardo Costa de Figueiredo; Marcone Augusto Leal de Oliveira; Bárbara Juliana Pinheiro Borges; Marcelo Antonio de Oliveira; Warley de Souza Borges; Keyller Bastos Borges
Journal:  J Pharm Anal       Date:  2018-01-17
  9 in total

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