Saiqa Bashir1, Muhammad Siddique Awan1, Muhammad Akhyar Farrukh2,3, Ravi Naidu4, Shahzad Akbar Khan5, Nagina Rafique1, Shaista Ali6, Imran Hayat1, Imtiaz Hussain1, Muhammad Zubair Khan7. 1. Department of Food Science and Technology, University of Poonch, Rawalakot, Pakistan. 2. Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. 3. Department of Basic and Applied Chemistry, University of Central Punjab, Lahore, Pakistan. 4. Global Centre for Environmental Remediation (GCER), University of Newcastle, Newcastle, Australia. 5. Department of Pathobiology, Faculty of Veterinary & Animal Sciences, University of Poonch, Rawalakot, Pakistan. 6. Department of Chemistry, Government College University of Lahore, Lahore, Pakistan. 7. Department of Plant Breeding and Molecular Genetics, University of Poonch, Rawalakot, Pakistan.
Abstract
Purpose: Recent advances in nanotechnology have given rise to the potential utilization of nanoparticles as food, nano-medicine/biomedicines. Patient: The study aimed to investigate the effects of nano-zinc oxide (nano-zinc) on the bio-assimilation of mineral (Zn) in mice, aged 3-6 weeks. Methods: ZnO nanoparticles were added to the basal diet as a supplement at amounts of 0.07, 0.14 and 0.21 mg/kg. The synthesized material was characterized by Fourier transform infrared spectrophotometer, particle size, scanning electron microscope, Thermogravimetric Analysis Thermal, X-ray diffraction spectrophotometer and Zeta potential. Results: In-vitro bioavailability of synthesized group ZnO (120 nm) was 43%, whereas for standard group ZnO (50 nm) was reported as 55%. In-vivo bioavailability of zinc oxide illustrated the maximum absorption level compared with the control. In-vivo toxicity was characterized as damage done to the liver and spleen tissues with a high dose of 0.21 mg/kg, while smaller doses indicated no toxic effects. Conclusion: The study provided important insights on the toxicological effects of ZnO nanoparticles, depending on dose rate and bio-assimilation, as well as particles, under various conditions (in-vitro and in-vivo). These findings will motivate further detailed research on nano-based medicine for alleviating malnutrition conditions.
Purpose: Recent advances in nanotechnology have given rise to the potential utilization of nanoparticles as food, nano-medicine/biomedicines. Patient: The study aimed to investigate the effects of nano-zinc oxide (nano-zinc) on the bio-assimilation of mineral (Zn) in mice, aged 3-6 weeks. Methods: ZnO nanoparticles were added to the basal diet as a supplement at amounts of 0.07, 0.14 and 0.21 mg/kg. The synthesized material was characterized by Fourier transform infrared spectrophotometer, particle size, scanning electron microscope, Thermogravimetric Analysis Thermal, X-ray diffraction spectrophotometer and Zeta potential. Results: In-vitro bioavailability of synthesized group ZnO (120 nm) was 43%, whereas for standard group ZnO (50 nm) was reported as 55%. In-vivo bioavailability of zinc oxide illustrated the maximum absorption level compared with the control. In-vivo toxicity was characterized as damage done to the liver and spleen tissues with a high dose of 0.21 mg/kg, while smaller doses indicated no toxic effects. Conclusion: The study provided important insights on the toxicological effects of ZnO nanoparticles, depending on dose rate and bio-assimilation, as well as particles, under various conditions (in-vitro and in-vivo). These findings will motivate further detailed research on nano-based medicine for alleviating malnutrition conditions.
Authors: P Surekha; A Sairam Kishore; A Srinivas; G Selvam; A Goparaju; P Neelakanta Reddy; P Balakrishna Murthy Journal: Cutan Ocul Toxicol Date: 2011-08-10 Impact factor: 1.820
Authors: Wan-Seob Cho; Rodger Duffin; Sarah E M Howie; Chris J Scotton; William A H Wallace; William Macnee; Mark Bradley; Ian L Megson; Ken Donaldson Journal: Part Fibre Toxicol Date: 2011-09-06 Impact factor: 9.400