Literature DB >> 3610818

A new antitumor antibiotic, FR-900482. II. Production, isolation, characterization and biological activity.

S Kiyoto, T Shibata, M Yamashita, T Komori, M Okuhara, H Terano, M Kohsaka, H Aoki, H Imanaka.   

Abstract

FR-900482 is a new antitumor antibiotic produced by a new actinomyces named Streptomyces sandaensis No. 6897. It exhibits potent cytotoxic activity against various tumor cells in vitro. Furthermore, it has weak antimicrobial activity against some Gram-positive or Gram-negative bacteria.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3610818     DOI： 10.7164/antibiotics.40.594

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae.

Authors:  P J Sheldon; D A Johnson; P R August; H W Liu; D H Sherman
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

Review 2.  Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.

Authors:  Robert M Williams
Journal:  J Org Chem       Date:  2011-04-12       Impact factor: 4.354

3.  Natural Products and Their Mimics as Targets of Opportunity for Discovery.

Authors:  Stephen F Martin
Journal:  J Org Chem       Date:  2017-09-15       Impact factor: 4.354

4.  Reactivity of aziridinomitosene derivatives related to FK317 in the presence of protic nucleophiles.

Authors:  Susan D Wiedner; Edwin Vedejs
Journal:  J Org Chem       Date:  2011-12-29       Impact factor: 4.354

5.  Phase I trial of FK973: description of a delayed vascular leak syndrome.

Authors:  R Pazdur; D H Ho; K Daugherty; W T Bradner; I H Krakoff; M N Raber
Journal:  Invest New Drugs       Date:  1991-11       Impact factor: 3.850

6.  A new antitumor antibiotic FR66973: clonogenic in vitro assessment of activity against human non-small cell lung carcinoma.

Authors:  F Kanzawa; Y Matsushima; C D Chiang; H Nakano; K Nakagawa; H Takahashi; S Morinaga; R Tsuchiya; Y Sasaki; K Eguchi
Journal:  Invest New Drugs       Date:  1987-12       Impact factor: 3.850

7.  N,N-DIIsopropyl-N-phosphonyl imines lead to efficient asymmetric synthesis of aziridine-2-carboxylic esters.

Authors:  Padmanabha V Kattamuri; Yiwen Xiong; Yi Pan; Guigen Li
Journal:  Org Biomol Chem       Date:  2013-05-28       Impact factor: 3.876

8.  Anti-cachectic effect of FK317, a novel anti-cancer agent, in colon26 and LX-1 models in mice.

Authors:  Y Naoe; I Kawamura; M Inami; S Matsumoto; F Nishigaki; S Tsujimoto; T Manda; K Shimomura
Journal:  Jpn J Cancer Res       Date:  1998-12

9.  FK317, a novel substituted dihydrobenzoxazine, exhibits potent antitumor activity against human tumor xenografts in nude mice.

Authors:  Y Naoe; M Inami; S Matsumoto; S Takagaki; T Fujiwara; S Yamazaki; I Kawamura; F Nishigaki; S Tsujimoto; T Manda; K Shimomura
Journal:  Jpn J Cancer Res       Date:  1998-12

10.  Mitomycins syntheses: a recent update.

Authors:  Jean-Christophe Andrez
Journal:  Beilstein J Org Chem       Date:  2009-07-08       Impact factor: 2.883
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.