Literature DB >> 3610817

A new antitumor antibiotic, FR-900482. I. Taxonomic studies on the producing strain: a new species of the genus Streptomyces.

M Iwami, S Kiyoto, H Terano, M Kohsaka, H Aoki, H Imanaka.   

Abstract

A new species in the genus Streptomyces, for which the name Streptomyces sandaensis sp. nov. is proposed, is described. Soil isolate strain No. 6897 (FERM-P 7654), produces a new antitumor substance FR-900482. The strain has a gray to red spore mass color, Rectus Flexibilis to Retinaculum-Apertum spore chain morphology, smooth spores, and is nonchromogenic. Strain No. 6897 is closely related to Streptomyces aburaviensis and Streptomyces nitrosporeus. But, there are many differences in cultural characteristics and in the utilization of carbohydrates.

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Year:  1987        PMID: 3610817     DOI: 10.7164/antibiotics.40.589

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  6 in total

Review 1.  Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.

Authors:  Robert M Williams
Journal:  J Org Chem       Date:  2011-04-12       Impact factor: 4.354

2.  Natural Products and Their Mimics as Targets of Opportunity for Discovery.

Authors:  Stephen F Martin
Journal:  J Org Chem       Date:  2017-09-15       Impact factor: 4.354

3.  Theoretical studies of the anti-tumor drug FR900482.

Authors:  Anne-Marie Sapse; Robert Rothchild; Duli C Jain; Gabriel A Hernandez
Journal:  J Mol Model       Date:  2007-09-09       Impact factor: 1.810

4.  Phase I trial of FK973: description of a delayed vascular leak syndrome.

Authors:  R Pazdur; D H Ho; K Daugherty; W T Bradner; I H Krakoff; M N Raber
Journal:  Invest New Drugs       Date:  1991-11       Impact factor: 3.850

5.  Anti-cachectic effect of FK317, a novel anti-cancer agent, in colon26 and LX-1 models in mice.

Authors:  Y Naoe; I Kawamura; M Inami; S Matsumoto; F Nishigaki; S Tsujimoto; T Manda; K Shimomura
Journal:  Jpn J Cancer Res       Date:  1998-12

6.  FK317, a novel substituted dihydrobenzoxazine, exhibits potent antitumor activity against human tumor xenografts in nude mice.

Authors:  Y Naoe; M Inami; S Matsumoto; S Takagaki; T Fujiwara; S Yamazaki; I Kawamura; F Nishigaki; S Tsujimoto; T Manda; K Shimomura
Journal:  Jpn J Cancer Res       Date:  1998-12
  6 in total

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